ID   COV362.4
AC   CVCL_2421
SY   COV362-4; COV-362.4
DR   BioSample; SAMN03473272
DR   cancercelllines; CVCL_2421
DR   Cell_Model_Passport; SIDM01630
DR   ECACC; 07071904
DR   GEO; GSM313709
DR   GEO; GSM1291134
DR   Progenetix; CVCL_2421
DR   Wikidata; Q54814343
RX   PubMed=8436435;
RX   PubMed=25230021;
RX   PubMed=25877200;
CC   Part of: OCCP ovarian cancer cell line panel.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1100; BRCA1; Simple; p.Pro871fs (c.2611_2612ins1); Zygosity=Homozygous (PubMed=25230021).
CC   Sequence variation: Mutation; HGNC; 1100; BRCA1; Simple; c.4095+1G>T; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=25230021).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=25230021).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ECACC=07071904; PubMed=25230021; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 14
ST   D16S539: 11
ST   D18S51: 13
ST   D19S433: 14
ST   D21S11: 31,32.2
ST   D2S1338: 24,25
ST   D3S1358: 16,18
ST   D5S818: 12,13 (PubMed=25877200)
ST   D5S818: 13 (PubMed=25230021)
ST   D7S820: 10,14
ST   D8S1179: 11
ST   FGA: 24
ST   Penta D: 9,11
ST   Penta E: 7,11
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 15,18
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2420 ! COV362
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
RX   PubMed=8436435; DOI=10.1002/ijc.2910530415;
RA   van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M.,
RA   Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H.,
RA   Cornelisse C.J., Schrier P.I.;
RT   "Establishment and characterization of 7 ovarian carcinoma cell lines
RT   and one granulosa tumor cell line: growth features and cytogenetics.";
RL   Int. J. Cancer 53:613-620(1993).
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988;
RA   Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M.,
RA   Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J.,
RA   Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J.,
RA   Helleman J.;
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:E103988-E103988(2014).
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).