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Cellosaurus C32TG (CVCL_2324)

[Text version]

Cell line name C32TG
Synonyms C32-TG; C32-r16TG; C32r16TG
Accession CVCL_2324
Resource Identification Initiative To cite this cell line use: C32TG (RRID:CVCL_2324)
Comments Population: Caucasian.
Doubling time: 37 hours (lot 09262006), ~43 hours (lot 10302018) (JCRB).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Discontinued: TKG; TKG 0190; probable.
Derived from sampling site: Skin.
Sequence variations
  • Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Ter157Serext*13 (c.470G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1097 (C32 [Human melanoma])
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC; JCRB; RCB

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81812
D7S8209,10,11 (RCB)
9,11 (ATCC; JCRB)
D13S31712
D16S53911,12
TH019.3
TPOX9
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections ATCC; CRL-1579
BCRC; 60269
ECACC; 96020925
JCRB; JCRB0227
RCB; RCB1929 - Discontinued
TKG; TKG 0190
Cell line databases/resources CLO; CLO_0002114
CGH-DB; 9287-4
IGRhCellID; C32TG
Anatomy/cell type resources BTO; BTO:0005451
Biological sample resources BioSample; SAMN03472091
Chemistry resources PharmacoDB; C32TG_155_2019
Encyclopedic resources Wikidata; Q54808139
Experimental variables resources EFO; EFO_0002119
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
Polymorphism and mutation databases Cosmic; 874386
Cosmic; 905201
Cosmic; 1007158
Progenetix; CVCL_2324
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number28