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Cellosaurus HeLa BU-25 (CVCL_2320)

[Text version]

Cell line name HeLa BU-25
Synonyms HeLa (BU-25); HeLa BU25; HeLa Bu25; HeLa/BU-25; HeLa(BU25); HeLa TK- (BU 25); Bu25 TK-; BU25 TK-; Bu25TK-
Accession CVCL_2320
Resource Identification Initiative To cite this cell line use: HeLa BU-25 (RRID:CVCL_2320)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: SNP array analysis.
Derived from sampling site: Uterus; cervix.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0058 (HeLa S3)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ECACC; RCB


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PubMed=5902315; DOI=10.1002/ijc.2910010105
Kit S., Dubbs D.R., Frearson P.M.
HeLa cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity.
Int. J. Cancer 1:19-30(1966)

PubMed=4639815; DOI=10.1016/0006-291X(72)90519-0
Kit S., Kaplan L.A., Leung W.-C., Trkula D.
Mitochondrial thymidine kinase of bromodeoxyuridine-resistant, kinase-deficient HeLa(BU25) cells.
Biochem. Biophys. Res. Commun. 49:1561-1567(1972)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cell line collections ECACC; 85022104
RCB; RCB0205
Cell line databases/resources CLO; CLO_0002050
CLO; CLO_0050929
CLDB; cl506
Encyclopedic resources Wikidata; Q54882520
Gene expression databases GEO; GSM827315
Polymorphism and mutation databases Cosmic; 753537
Progenetix; CVCL_2320
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number15