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Cellosaurus HeLa BU-25 (CVCL_2320)

[Text version]
Cell line name HeLa BU-25
Synonyms HeLa (BU-25); HeLa BU25; HeLa Bu25; HeLa/BU-25; HeLa(BU25); HeLa TK- (BU 25); Bu25 TK-; BU25 TK-; Bu25TK-
Accession CVCL_2320
Resource Identification Initiative To cite this cell line use: HeLa BU-25 (RRID:CVCL_2320)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0058 (HeLa S3)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ECACC=85022104; RCB=RCB0205

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8208,12
D13S31714
D16S5399,10
TH017
TPOX8,12
vWA16,18

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Publications

PubMed=5902315; DOI=10.1002/ijc.2910010105
Saul Kit, Del Rose Dubbs, Peter M. Frearson;
HeLa cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity.
Int. J. Cancer 1:19-30(1966)

PubMed=4639815; DOI=10.1016/0006-291X(72)90519-0
Saul Kit, Lawrence A. Kaplan, Wai-Choi Leung, David Trkula;
Mitochondrial thymidine kinase of bromodeoxyuridine-resistant, kinase-deficient HeLa(BU25) cells.
Biochem. Biophys. Res. Commun. 49:1561-1567(1972)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ECACC; 85022104
RCB; RCB0205
Cell line databases/resources CLO; CLO_0002050
CLO; CLO_0050929
CLDB; cl506
cancercelllines; CVCL_2320
Encyclopedic resources Wikidata; Q54882520
Gene expression databases GEO; GSM827315
Polymorphism and mutation databases Cosmic; 753537
Progenetix; CVCL_2320
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21