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Cellosaurus A375-C6 (CVCL_2295)

[Text version]
Cell line name A375-C6
Accession CVCL_2295
Resource Identification Initiative To cite this cell line use: A375-C6 (RRID:CVCL_2295)
Comments Population: Caucasian.
Omics: Variations; SNP array analysis.
Misspelling: A373-C6; CLO=CLO_0037118; Note=Also in Sigma-Aldrich catalog.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ECACC=97011321

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S8209
D13S31711
D16S5399
TH018
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375-C6
Publications

PubMed=2584706; DOI=10.4049/jimmunol.143.11.3538
Yoshihiro Morinaga, Hiroshi Suzuki, Fumihiko Takatsuki, Yukio Akiyama, Tadayoshi Taniyama, Kouji Matsushima, Kikuo Onozaki;
Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines.
J. Immunol. 143:3538-3542(1989)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ECACC; 97011321
Cell line databases/resources CLO; CLO_0037118
cancercelllines; CVCL_2295
LINCS_LDP; LCL-1284
Encyclopedic resources Wikidata; Q54606779
Gene expression databases GEO; GSM827328
Polymorphism and mutation databases Progenetix; CVCL_2295
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30