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Cellosaurus A375-C6 (CVCL_2295)

[Text version]
Cell line name A375-C6
Accession CVCL_2295
Resource Identification Initiative To cite this cell line use: A375-C6 (RRID:CVCL_2295)
Comments Population: Caucasian.
Omics: SNP array analysis.
Misspelling: A373-C6; CLO=CLO_0037118; Note=Also in Sigma-Aldrich catalog.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ECACC=97011321


Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=A375-C6

PubMed=2584706; DOI=10.4049/jimmunol.143.11.3538
Morinaga Y., Suzuki H., Takatsuki F., Akiyama Y., Taniyama T., Matsushima K., Onozaki K.
Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines.
J. Immunol. 143:3538-3542(1989)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cell line collections (Providers) ECACC; 97011321
Cell line databases/resources CLO; CLO_0037118
cancercelllines; CVCL_2295
Encyclopedic resources Wikidata; Q54606779
Gene expression databases GEO; GSM827328
Polymorphism and mutation databases Progenetix; CVCL_2295
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number27