Cell line name |
A375-C6 |
Accession |
CVCL_2295 |
Resource Identification Initiative |
To cite this cell line use: A375-C6 (RRID:CVCL_2295) |
Comments |
Population: Caucasian. Omics: Variations; SNP array analysis. Misspelling: A373-C6; CLO=CLO_0037118; Note=Also in Sigma-Aldrich catalog. Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
Disease |
Amelanotic melanoma (NCIt: C3802) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0132 (A-375) |
Sex of cell |
Female |
Age at sampling |
54Y |
Category |
Cancer cell line |
STR profile |
Source(s): ECACC=97011321
Markers: Run an STR similarity search on this cell line |
Web pages |
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375-C6 |
Publications | PubMed=2584706; DOI=10.4049/jimmunol.143.11.3538 Yoshihiro Morinaga, Hiroshi Suzuki, Fumihiko Takatsuki, Yukio Akiyama, Tadayoshi Taniyama, Kouji Matsushima, Kikuo Onozaki; Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines. J. Immunol. 143:3538-3542(1989) PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) |
Cross-references |
Cell line collections (Providers) |
ECACC; 97011321
|
Cell line databases/resources |
CLO; CLO_0037118
cancercelllines; CVCL_2295
LINCS_LDP; LCL-1284
|
Encyclopedic resources |
Wikidata; Q54606779
|
Gene expression databases |
GEO; GSM827328
|
Polymorphism and mutation databases |
Progenetix; CVCL_2295
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 30 |
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