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Cellosaurus A375-C5 (CVCL_2294)

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Cell line name A375-C5
Synonyms A375Cl-5
Accession CVCL_2294
Resource Identification Initiative To cite this cell line use: A375-C5 (RRID:CVCL_2294)
Comments Population: Caucasian.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375-C5
Publications

PubMed=2584706; DOI=10.4049/jimmunol.143.11.3538
Yoshihiro Morinaga, Hiroshi Suzuki, Fumihiko Takatsuki, Yukio Akiyama, Tadayoshi Taniyama, Kouji Matsushima, Kikuo Onozaki;
Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines.
J. Immunol. 143:3538-3542(1989)

Cross-references
Cell line collections (Providers) ECACC; 97011320
Cell line databases/resources cancercelllines; CVCL_2294
Encyclopedic resources Wikidata; Q54606776
Polymorphism and mutation databases Cosmic; 932715
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25