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Cellosaurus UT-7 (CVCL_2233)

[Text version]
Cell line name UT-7
Synonyms UT7
Accession CVCL_2233
Resource Identification Initiative To cite this cell line use: UT-7 (RRID:CVCL_2233)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Characteristics: CSF2 dependent.
Doubling time: ~36-48 hours (PubMed=1824823); ~70 hours (DSMZ=ACC-137).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.783_919del137; Zygosity=Unspecified (PubMed=1571549).
HLA typing Source: DSMZCellDive=ACC-137
Class I
HLA-AA*02:01:01,11:01:01
HLA-BB*55:02:01,55:02:01
HLA-CC*01:02:01,01:02:01
Class II
HLA-DPDPA1*01:03:01,02:02:02
DPB1*03:01:01,03:01:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*08:02:01,08:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.07
Native American0
East Asian, North82.57
East Asian, South12
South Asian0
European, North0
European, South3.36
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5202 (UT-7/Epo)CVCL_5203 (UT-7/GM)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000120; DSMZ=ACC-137; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,23
D3S135816
D5S81812
D7S8208
D8S117911,15
D13S3178
D16S53910,12
D18S5114,17
D19S43314,14.2 (CCRID=1101HUM-PUMC000120)
14,15 (DSMZ=ACC-137)
D21S1131.2
FGA23
Penta D9,11
Penta E16,17
TH016,9
TPOX10
vWA14,18 (DSMZ=ACC-137; PubMed=25877200)
14,18,19 (CCRID=1101HUM-PUMC000120)

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=UT-7
Publications

PubMed=2217443
Yasusada Miura, Norio Komatsu, Toshio Suda;
Growth and differentiation of two human megakaryoblastic cell lines CMK and UT-7.
Prog. Clin. Biol. Res. 356:259-270(1990)

PubMed=1824823
Norio Komatsu, Hiromitsu Nakauchi, Akiyoshi Miwa, Toshiki Ishihara, Mitsuoki Eguchi, Masaaki Moroi, Masayuki Okada, Yuko Sato, Hideho Wada, Yoshihito Yawata, Toshio Suda, Yasusada Miura;
Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.
Cancer Res. 51:341-348(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Koichi Sugimoto, Hideo Toyoshima, Ryuichi Sakai, Kiyoshi Miyagawa, Koichi Hagiwara, Fuyuki Ishikawa, Fumimaro Takaku, Yoshio Yazaki, Hisamaru Hirai;
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=7647001; DOI=10.1111/j.1365-2141.1995.tb05591.x
Etsuro Ito, Mikio Kasai, Yasuhide Hayashi, Tsutomu Toki, Koji Arai, Shinkichi Yokoyama, Koji Kato, Naoki Tachibana, Masayuki Yamamoto, Masaru Yokoyama;
Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome.
Br. J. Haematol. 90:607-614(1995)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Hans Gunther Drexler, Margarete Zaborski, Hilmar Quentmeier;
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4
Kaoru Tohyama;
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Marcin Majka, Tomasz Rozmyslowicz, Marek J. Honczarenko, Janina Ratajczak, Mariusz A. Wasik, Glen N. Gaulton, Mariusz Zdzislaw Ratajczak;
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Ayana Kon, Lee-Yung Shih, Masashi Minamino, Masashi Sanada, Yuichi Shiraishi, Yasunobu Nagata, Ken-ichi Yoshida, Yusuke Okuno, Masashige Bando, Ryuichiro Nakato, Shumpei Ishikawa ...Show all 41 authors... , Aiko Sato-Otsubo, Genta Nagae, Aiko Nishimoto, Claudia Haferlach, Daniel Nowak, Yusuke Sato, Tamara Alpermann, Masao Nagasaki, Teppei Shimamura, Hiroko Tanaka, Kenichi Chiba, Ryo Yamamoto, Tomoyuki Yamaguchi, Makoto Otsu, Naoshi Obara, Mamiko Sakata-Yanagimoto, Tsuyoshi Nakamaki, Ken Ishiyama, Florian Nolte, Wolf-Karsten Hofmann, Shuichi Miyawaki, Shigeru Chiba, Hiraku Mori, Hiromitsu Nakauchi, Harold Phillip Koeffler, Hiroyuki Aburatani, Torsten Haferlach, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa; Show fewer authors
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-137
Cell line databases/resources CLO; CLO_0009490
CLDB; cl5398
cancercelllines; CVCL_2233
CCRID; 1101HUM-PUMC000120
Cell_Model_Passport; SIDM01908
DepMap; ACH-001230
DSMZCellDive; ACC-137
Lonza; 41
Anatomy/cell type resources BTO; BTO_0000960
Biological sample resources BioSample; SAMN03472875
BioSample; SAMN10988426
Chemistry resources ChEMBL-Cells; CHEMBL3307293
ChEMBL-Targets; CHEMBL614057
PharmacoDB; UT7_1649_2019
PubChem_Cell_line; CVCL_2233
Encyclopedic resources Wikidata; Q54992037
Experimental variables resources EFO; EFO_0022372
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM743411
GEO; GSM887730
GEO; GSM888825
GEO; GSM1374979
Polymorphism and mutation databases Cosmic; 787487
Cosmic; 919130
Cosmic; 975312
Cosmic; 1012128
Cosmic; 1281362
Cosmic; 1465951
Cosmic; 2089659
IARC_TP53; 2200
Progenetix; CVCL_2233
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number36