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Cellosaurus UPCI-SCC-116 (CVCL_2228)

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Cell line name UPCI-SCC-116
Synonyms UPCI:SCC116; UPCISCC116; SCC116
Accession CVCL_2228
Resource Identification Initiative To cite this cell line use: UPCI-SCC-116 (RRID:CVCL_2228)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~80 hours (DSMZ=ACC-663).
Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
Sequence variations
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Gly17Val (c.50G>T); Zygosity=Unspecified (DepMap=ACH-001698).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=12872257; DepMap=ACH-001698).
Disease Alveolar ridge squamous cell carcinoma (NCIt: C170774)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001698; DSMZ=ACC-663

Markers:
AmelogeninX
CSF1PO10,12
D2S133820
D3S135815,16
D5S8189,13
D7S8208,12
D8S117913,14
D13S3179,11
D16S53911,12
D18S5114
D19S43312,14
D21S1130
FGA20,21
Penta D11
Penta E7,10
TH019.3 (DepMap=ACH-001698)
10 (DSMZ=ACC-663)
TPOX8,10
vWA15,18

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Publications

PubMed=12872257; DOI=10.1002/humu.10248
Cheryl A. Telmer, Ji-Yan An, David E. Malehorn, Xue-Mei Zeng, Susanne M. Gollin, Chandramohan S. Ishwad, Jonathan W. Jarvik;
Detection and assignment of TP53 mutations in tumor DNA using peptide mass signature genotyping.
Hum. Mutat. 22:158-165(2003)

PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692
Jason S. White, Joel L. Weissfeld, Camille C.R. Ragin, Karen M. Rossie, Christa Lese Martin, Michele Shuster, Chandramohan S. Ishwad, John C. Law, Eugene Nicholas Myers, Jonas T. Johnson, Susanne M. Gollin;
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Oral Oncol. 43:701-712(2007)

PubMed=24142626; DOI=10.1002/gcc.22115; PMCID=PMC5520977
Rahul Atul Parikh, Leonard J. Appleman, Julie E. Bauman, Madhav Sankunny, Dale W. Lewis, Anda Vlad, Susanne M. Gollin;
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Genes Chromosomes Cancer 53:25-37(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-663
Cell line databases/resources cancercelllines; CVCL_2228
DepMap; ACH-001698
DSMZCellDive; ACC-663
Biological sample resources BioSample; SAMN03473477
Encyclopedic resources Wikidata; Q54991671
Polymorphism and mutation databases IARC_TP53; 18363
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23