ID   UPCI-SCC-116
AC   CVCL_2228
SY   UPCI:SCC116; UPCISCC116; SCC116
DR   BioSample; SAMN03473477
DR   cancercelllines; CVCL_2228
DR   DepMap; ACH-001698
DR   DSMZ; ACC-663
DR   DSMZCellDive; ACC-663
DR   IARC_TP53; 18363
DR   Wikidata; Q54991671
RX   PubMed=12872257;
RX   PubMed=17112776;
RX   PubMed=24142626;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: ~80 hours (DSMZ=ACC-663).
CC   Sequence variation: Mutation; HGNC; HGNC:667; RHOA; Simple; p.Gly17Val (c.50G>T); Zygosity=Unspecified (DepMap=ACH-001698).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=12872257; DepMap=ACH-001698).
CC   Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
ST   Source(s): DepMap=ACH-001698; DSMZ=ACC-663
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9,11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D19S433: 12,14
ST   D21S11: 30
ST   D2S1338: 20
ST   D3S1358: 15,16
ST   D5S818: 9,13
ST   D7S820: 8,12
ST   D8S1179: 13,14
ST   FGA: 20,21
ST   Penta D: 11
ST   Penta E: 7,10
ST   TH01: 9.3 (DepMap=ACH-001698)
ST   TH01: 10 (DSMZ=ACC-663)
ST   TPOX: 8,10
ST   vWA: 15,18
DI   NCIt; C170774; Alveolar ridge squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692;
RA   White, Jason S.
RA   Weissfeld, Joel L.
RA   Ragin, Camille C.R.
RA   Rossie, Karen M.
RA   Martin, Christa Lese
RA   Shuster, Michele
RA   Ishwad, Chandramohan S.
RA   Law, John C.
RA   Myers, Eugene Nicholas
RA   Johnson, Jonas T.
RA   Gollin, Susanne M.
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=12872257; DOI=10.1002/humu.10248;
RA   Telmer, Cheryl A.
RA   An, Ji-Yan
RA   Malehorn, David E.
RA   Zeng, Xue-Mei
RA   Gollin, Susanne M.
RA   Ishwad, Chandramohan S.
RA   Jarvik, Jonathan W.
RT   "Detection and assignment of TP53 mutations in tumor DNA using peptide
RT   mass signature genotyping.";
RL   Hum. Mutat. 22:158-165(2003).
//
RX   PubMed=24142626; DOI=10.1002/gcc.22115; PMCID=PMC5520977;
RA   Parikh, Rahul Atul
RA   Appleman, Leonard J.
RA   Bauman, Julie E.
RA   Sankunny, Madhav
RA   Lewis, Dale W.
RA   Vlad, Anda
RA   Gollin, Susanne M.
RT   "Upregulation of the ATR-CHEK1 pathway in oral squamous cell
RT   carcinomas.";
RL   Genes Chromosomes Cancer 53:25-37(2014).
//