ID   UPCI-SCC-116
AC   CVCL_2228
SY   UPCI:SCC116; UPCISCC116; SCC116
DR   BioSample; SAMN03473477
DR   cancercelllines; CVCL_2228
DR   DepMap; ACH-001698
DR   DSMZ; ACC-663
DR   DSMZCellDive; ACC-663
DR   IARC_TP53; 18363
DR   Wikidata; Q54991671
RX   PubMed=12872257;
RX   PubMed=17112776;
RX   PubMed=24142626;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: ~80 hours (DSMZ=ACC-663).
CC   Sequence variation: Mutation; HGNC; HGNC:667; RHOA; Simple; p.Gly17Val (c.50G>T); Zygosity=Unspecified (DepMap=ACH-001698).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=12872257; DepMap=ACH-001698).
CC   Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004103.
ST   Source(s): DepMap=ACH-001698; DSMZ=ACC-663
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9,11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D19S433: 12,14
ST   D21S11: 30
ST   D2S1338: 20
ST   D3S1358: 15,16
ST   D5S818: 9,13
ST   D7S820: 8,12
ST   D8S1179: 13,14
ST   FGA: 20,21
ST   Penta D: 11
ST   Penta E: 7,10
ST   TH01: 9.3 (DepMap=ACH-001698)
ST   TH01: 10 (DSMZ=ACC-663)
ST   TPOX: 8,10
ST   vWA: 15,18
DI   NCIt; C170774; Alveolar ridge squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=12872257; DOI=10.1002/humu.10248;
RA   Telmer C.A., An J.-Y., Malehorn D.E., Zeng X.-M., Gollin S.M.,
RA   Ishwad C.S., Jarvik J.W.;
RT   "Detection and assignment of TP53 mutations in tumor DNA using peptide
RT   mass signature genotyping.";
RL   Hum. Mutat. 22:158-165(2003).
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692;
RA   White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L.,
RA   Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T.,
RA   Gollin S.M.;
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=24142626; DOI=10.1002/gcc.22115; PMCID=PMC5520977;
RA   Parikh R.A., Appleman L.J., Bauman J.E., Sankunny M., Lewis D.W.,
RA   Vlad A., Gollin S.M.;
RT   "Upregulation of the ATR-CHEK1 pathway in oral squamous cell
RT   carcinomas.";
RL   Genes Chromosomes Cancer 53:25-37(2014).
//