Cellosaurus cell line SH-2 [Human leukemia] (CVCL

Cellosaurus SH-2 [Human leukemia] (CVCL_2190)

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Cell line name

SH-2 [Human leukemia]

Accession

CVCL_2190

Resource Identification Initiative

To cite this cell line use: SH-2 [Human leukemia] (RRID:CVCL_2190)

Comments

Population: Chinese.
Doubling time: ~80 hours (DSMZ=ACC-643).
Karyotypic information: Has lost chromosome Y (PubMed=18715689; PubMed=19954598).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln192His (c.576G>T); ClinVar=VCV000922531; Zygosity=Hemizygous (PubMed=18715689; PubMed=19954598).

Disease

Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

35Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-643; PubMed=18715689

Markers:

Amelogenin	X
CSF1PO	10
D2S1338	18,20
D3S1358	15,17
D5S818	10,11
D7S820	12
D8S1179	14,15
D13S317	10,12
D16S539	9
D18S51	13,22
D19S433	14,15
D21S11	30
FGA	23,25
Penta D	9
Penta E	15,19
TH01	9
TPOX	8,11
vWA	18,20

Publications

PubMed=18715689; DOI=10.1016/j.exphem.2008.06.013
Hui-Ying Qiu, Yong-Quan Xue, Jun Zhang, Jin-Lan Pan, Hai-Ping Dai, Ya-Fang Wu, Yong Wang, Su-Ning Chen, De-Pei Wu;
Establishment and characterization of a new human acute myelocytic leukemia cell line SH-2 with a loss of Y chromosome, a derivative chromosome 16 resulting from an unbalanced translocation between chromosomes 16 and 17, monosomy 17, trisomy 19, and p53 alteration.
Exp. Hematol. 36:1487-1495(2008)

PubMed=19954598; DOI=10.3760/cma.j.issn.0253-2727.2009.07.009
Hui-Ying Qiu, Yong-Quan Xue, Jun Zhang, Hai-Ping Dai, Jin-Lan Pan, Ya-Fang Wu, Su-Ning Chen, Yong Wang, Juan Shen, Ai-Ning Sun, De-Pei Wu;
Establishment and characterization of a new human myeloid leukemia cell line SH-2.
Zhonghua Xue Ye Xue Za Zhi 30:458-463(2009)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-643

Cell line databases/resources

cancercelllines; CVCL_2190
DSMZCellDive; ACC-643

Biological sample resources

BioSample; SAMN03473457

Encyclopedic resources

Wikidata; Q54953197

Gene expression databases

GEO; GSM1446761

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number