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Cellosaurus PNT1A (CVCL_2163)

[Text version]
Cell line name PNT1A
Synonyms PNT1a; PNT-1A; PNT1-a; PNT1/A
Accession CVCL_2163
Resource Identification Initiative To cite this cell line use: PNT1A (RRID:CVCL_2163)
Comments Doubling time: 29.93 +- 1.29 hours (PubMed=21556542).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pMK16).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Prostate, epithelium; UBERON=UBERON_0000428.
Cell type: Epithelial cell of prostate; CL=CL_0002231.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4804 (PNT1)
Children:
CVCL_JX33 (PNT1A serum free)
Sex of cell Male
Age at sampling 35Y
Category Transformed cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX,Y
D8S117910,12
D18S5116
D21S1127,28
FGA24
TH016
vWA17,19

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Publications

PubMed=7558421; DOI=10.1002/ijc.2910620613
Armelle Degeorges, Francoise Hoffschir, Olivier Cussenot, Christiane Gauville, Alain Le Duc, Bernard Dutrillaux, Fabien Calvo;
Recurrent cytogenetic alterations of prostate carcinoma and amplification of c-myc or epidermal growth factor receptor in subclones of immortalized PNT1 human prostate epithelial cell line.
Int. J. Cancer 62:724-731(1995)

PubMed=21556542; DOI=10.3892/ijo.6.2.333
Philippe Berthon, Olivier Cussenot, Lucy Hopwood, Alain Le Duc, Norman J. Maitland;
Functional expression of SV40 in normal human prostatic epithelial and fibroblastic cells: differentiation pattern of nontumorigenic cell-lines.
Int. J. Oncol. 6:333-343(1995)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11694337; DOI=10.1016/S0303-7207(01)00669-4
Christophe Avances, Virginie Georget, Beatrice Terouanne, Francesco Orio Jr., Olivier Cussenot, Nicolas Mottet, Pierre Costa, Charles Sultan;
Human prostatic cell line PNT1A, a useful tool for studying androgen receptor transcriptional activity and its differential subnuclear localization in the presence of androgens and antiandrogens.
Mol. Cell. Endocrinol. 184:13-24(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ECACC; 95012614
Cell line databases/resources CLO; CLO_0008475
CLDB; cl3926
Anatomy/cell type resources BTO; BTO_0003068
Chemistry resources ChEMBL-Cells; CHEMBL4513117
ChEMBL-Targets; CHEMBL4513131
PubChem_Cell_line; CVCL_2163
Encyclopedic resources Wikidata; Q54947679
Gene expression databases GEO; GSM827411
GEO; GSM1374835
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27