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Cellosaurus P815 (CVCL_2154)

[Text version]
Cell line name P815
Synonyms P-815; P 815
Accession CVCL_2154
Resource Identification Initiative To cite this cell line use: P815 (RRID:CVCL_2154)
Comments Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Doubling time: ~18-22 hours (DSMZ=ACC-1).
Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Omics: SNP array analysis.
Misspelling: P825; Note=Occasionally.
Sequence variations
  • Mutation; MGI; MGI:96677; Kit; Simple; p.Asp818Tyr (c.2452G>T) (D814Y); Zygosity=Unspecified (PubMed=7513208; PubMed=10210327).
Disease Mouse mast cell neoplasm (NCIt: C21632)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Children:
CVCL_A9JC (P815 Hsp65-IL-2)CVCL_4Z63 (P815 MB)CVCL_4269 (P815-1-1)
CVCL_F735 (P815-X2)CVCL_C0DF (P815.Trh4)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=31220119

Mouse STR 1-116,17
Mouse STR 1-214,17,18
Mouse STR 2-115
Mouse STR 3-213,14
Mouse STR 4-220.3
Mouse STR 5-513 (PubMed=31220119)
13,14 (DSMZ)
Mouse STR 6-417 (DSMZ)
17,18 (PubMed=31220119)
Mouse STR 6-712 (PubMed=31220119)
12,13 (DSMZ)
Mouse STR 7-127
Mouse STR 8-116
Mouse STR 11-216,17,18
Mouse STR 12-116,17 (DSMZ)
17 (PubMed=31220119)
Mouse STR 13-117,18
Mouse STR 15-320.3,21.3 (PubMed=31220119)
21.3 (DSMZ)
Mouse STR 17-217
Mouse STR 18-317 (PubMed=31220119)
17,18 (DSMZ)
Mouse STR 19-212
Mouse STR X-127 (PubMed=31220119)
27,28 (DSMZ)

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-232.html

PubMed=4208429; DOI=10.1038/249049a0
Ralph P., Nakoinz I.
Lipopolysaccharides inhibit lymphosarcoma cells of bone marrow orgin.
Nature 249:49-51(1974)

PubMed=1234049; DOI=10.1002/eji.1830050208
Kiessling R., Klein E., Wigzell H.
'Natural' killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype.
Eur. J. Immunol. 5:112-117(1975)

Yanagisawa M., Hasegawa H., Ichiyama A., Hosoda S., Nakamura W.
Comparison of serotonin-producing murine mastocytomas, P-815 and FMA3: determination of tryptophan hydroxylase, aromatic L-amino acid decarboxylase, and cellular concentration of tryptophan, 5- hydroxytryprophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid.
Biomed. Res. 5:19-28(1984)

PubMed=3792703; DOI=10.1111/j.1432-0436.1986.tb00568.x
Leenen P.J.M., Jansen A.M.A.C., van Ewijk W.
Murine macrophage cell lines can be ordered in a linear differentiation sequence.
Differentiation 32:157-164(1986)

PubMed=7513208; DOI=10.1182/blood.V83.9.2619.2619
Tsujimura T., Furitsu T., Morimoto M., Isozaki K., Nomura S., Matsuzawa Y., Kitamura Y., Kanakura Y.
Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation.
Blood 83:2619-2626(1994)

PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7
London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C., Geissler E.N.
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.
Exp. Hematol. 27:689-697(1999)

PubMed=18432777; DOI=10.1002/0471142735.im2004s43
Gajewski T.F., Markiewicz M.A., Uyttenhove C.
The P815 mastocytoma tumor model.
Curr. Protoc. Immunol. 43:20.4.1-20.4.18(2001)

PubMed=25277546; DOI=10.1186/1471-2164-15-847
Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W., Morse H.C. III, Pardo-Manuel de Villena F.
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.
BMC Genomics 15:847.1-847.11(2014)

PubMed=31220119; DOI=10.1371/journal.pone.0218412
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)

Cell line collections (Providers) ATCC; TIB-64
BCRC; 60178
BCRJ; 0200
CLS; 400242
JCRB; IFO50029 - Discontinued
KCB; KCB 93032YJ
NCBI_Iran; C550
RCB; RCB1167
TKG; TKG 0168
Cell line databases/resources CLO; CLO_0008340
CLO; CLO_0008341
CLO; CLO_0050217
CLDB; cl3784
CLDB; cl3785
CLDB; cl5244
CCRID; 1101MOU-PUMC000114
DSMZCellDive; ACC-1
Lonza; 187
Anatomy/cell type resources BTO; BTO:0000985
Biological sample resources BioSample; SAMN11397663
Chemistry resources ChEMBL-Cells; CHEMBL3307568
ChEMBL-Targets; CHEMBL614226
PubChem_Cell_line; CVCL_2154
Encyclopedic resources Wikidata; Q54937317
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number31