ID   P815
AC   CVCL_2154
SY   P-815; P 815
DR   BTO; BTO:0000985
DR   CLO; CLO_0008340
DR   CLO; CLO_0008341
DR   CLO; CLO_0050217
DR   CLDB; cl3784
DR   CLDB; cl3785
DR   CLDB; cl5244
DR   ATCC; TIB-64
DR   BCRC; 60178
DR   BCRJ; 0200
DR   BioSample; SAMN11397663
DR   CCRID; 1101MOU-PUMC000114
DR   CCRID; 3101MOUSCSP516
DR   CCRID; 3101MOUTCM12
DR   CCRID; 4201MOU-CCTCC00608
DR   CCTCC; GDC0608
DR   ChEMBL-Cells; CHEMBL3307568
DR   ChEMBL-Targets; CHEMBL614226
DR   CLS; 400242
DR   DSMZ; ACC-1
DR   DSMZCellDive; ACC-1
DR   IZSLER; BS TCL 118
DR   JCRB; IFO50029
DR   JCRB; JCRB0078
DR   KCB; KCB 93032YJ
DR   Lonza; 187
DR   NCBI_Iran; C550
DR   PubChem_Cell_line; CVCL_2154
DR   RCB; RCB1167
DR   TKG; TKG 0168
DR   Wikidata; Q54937317
RX   DOI=10.2220/biomedres.5.19;
RX   PubMed=1234049;
RX   PubMed=3792703;
RX   PubMed=4208429;
RX   PubMed=7513208;
RX   PubMed=10210327;
RX   PubMed=18432777;
RX   PubMed=25277546;
RX   PubMed=31220119;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-232.html
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-233.html
CC   Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
CC   Doubling time: ~18-22 hours (DSMZ=ACC-1).
CC   Sequence variation: Mutation; MGI; MGI:96677; Kit; Simple; p.Asp818Tyr (c.2452G>T) (D814Y); Zygosity=Unspecified (PubMed=7513208; PubMed=10210327).
CC   Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Omics: SNP array analysis.
CC   Misspelling: P825; Note=Occasionally.
CC   Discontinued: JCRB; IFO50029; true.
CC   Breed/subspecies: DBA/2.
ST   Source(s): DSMZ; PubMed=31220119
ST   Mouse STR 1-1: 16,17
ST   Mouse STR 1-2: 14,17,18
ST   Mouse STR 11-2: 16,17,18
ST   Mouse STR 12-1: 16,17 (DSMZ)
ST   Mouse STR 12-1: 17 (PubMed=31220119)
ST   Mouse STR 13-1: 17,18
ST   Mouse STR 15-3: 20.3,21.3 (PubMed=31220119)
ST   Mouse STR 15-3: 21.3 (DSMZ)
ST   Mouse STR 17-2: 17
ST   Mouse STR 18-3: 17 (PubMed=31220119)
ST   Mouse STR 18-3: 17,18 (DSMZ)
ST   Mouse STR 19-2: 12
ST   Mouse STR 2-1: 15
ST   Mouse STR 3-2: 13,14
ST   Mouse STR 4-2: 20.3
ST   Mouse STR 5-5: 13 (PubMed=31220119)
ST   Mouse STR 5-5: 13,14 (DSMZ)
ST   Mouse STR 6-4: 17 (DSMZ)
ST   Mouse STR 6-4: 17,18 (PubMed=31220119)
ST   Mouse STR 6-7: 12 (PubMed=31220119)
ST   Mouse STR 6-7: 12,13 (DSMZ)
ST   Mouse STR 7-1: 27
ST   Mouse STR 8-1: 16
ST   Mouse STR X-1: 27 (PubMed=31220119)
ST   Mouse STR X-1: 27,28 (DSMZ)
DI   NCIt; C21632; Mouse mast cell neoplasm
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 31
//
RX   DOI=10.2220/biomedres.5.19;
RA   Yanagisawa M., Hasegawa H., Ichiyama A., Hosoda S., Nakamura W.;
RT   "Comparison of serotonin-producing murine mastocytomas, P-815 and
RT   FMA3: determination of tryptophan hydroxylase, aromatic L-amino acid
RT   decarboxylase, and cellular concentration of tryptophan, 5-
RT   hydroxytryprophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic
RT   acid.";
RL   Biomed. Res. 5:19-28(1984).
//
RX   PubMed=1234049; DOI=10.1002/eji.1830050208;
RA   Kiessling R., Klein E., Wigzell H.;
RT   "'Natural' killer cells in the mouse. I. Cytotoxic cells with
RT   specificity for mouse Moloney leukemia cells. Specificity and
RT   distribution according to genotype.";
RL   Eur. J. Immunol. 5:112-117(1975).
//
RX   PubMed=3792703; DOI=10.1111/j.1432-0436.1986.tb00568.x;
RA   Leenen P.J.M., Jansen A.M.A.C., van Ewijk W.;
RT   "Murine macrophage cell lines can be ordered in a linear
RT   differentiation sequence.";
RL   Differentiation 32:157-164(1986).
//
RX   PubMed=4208429; DOI=10.1038/249049a0;
RA   Ralph P., Nakoinz I.;
RT   "Lipopolysaccharides inhibit lymphosarcoma cells of bone marrow
RT   orgin.";
RL   Nature 249:49-51(1974).
//
RX   PubMed=7513208; DOI=10.1182/blood.V83.9.2619.2619;
RA   Tsujimura T., Furitsu T., Morimoto M., Isozaki K., Nomura S.,
RA   Matsuzawa Y., Kitamura Y., Kanakura Y.;
RT   "Ligand-independent activation of c-kit receptor tyrosine kinase in a
RT   murine mastocytoma cell line P-815 generated by a point mutation.";
RL   Blood 83:2619-2626(1994).
//
RX   PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7;
RA   London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C.,
RA   Geissler E.N.;
RT   "Spontaneous canine mast cell tumors express tandem duplications in
RT   the proto-oncogene c-kit.";
RL   Exp. Hematol. 27:689-697(1999).
//
RX   PubMed=18432777; DOI=10.1002/0471142735.im2004s43;
RA   Gajewski T.F., Markiewicz M.A., Uyttenhove C.;
RT   "The P815 mastocytoma tumor model.";
RL   Curr. Protoc. Immunol. 43:20.4.1-20.4.18(2001).
//
RX   PubMed=25277546; DOI=10.1186/1471-2164-15-847;
RA   Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W.,
RA   Morse H.C. III, Pardo-Manuel de Villena F.;
RT   "SNP array profiling of mouse cell lines identifies their strains of
RT   origin and reveals cross-contamination and widespread aneuploidy.";
RL   BMC Genomics 15:847.1-847.11(2014).
//
RX   PubMed=31220119; DOI=10.1371/journal.pone.0218412;
RA   Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S.,
RA   Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H.,
RA   Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B.,
RA   Natoli M., Bauer B.A., Gollin S.M., Lewis D.W., Reid Y.A.;
RT   "Interlaboratory study to validate a STR profiling method for
RT   intraspecies identification of mouse cell lines.";
RL   PLoS ONE 14:E0218412-E0218412(2019).
//