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Cellosaurus NGP (CVCL_2141)

[Text version]
Cell line name NGP
Accession CVCL_2141
Resource Identification Initiative To cite this cell line use: NGP (RRID:CVCL_2141)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~50-70 hours (DSMZ=ACC-676).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys141Trp (c.423C>G); ClinVar=VCV000376564; Zygosity=Unspecified (DepMap=ACH-001366).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HG07 (N_M5R1)CVCL_HG08 (N_N20R1)CVCL_0B58 (NGP-C4)
CVCL_AX38 (NGP.1A.TR1)CVCL_RS68 (NGPrBORTE20)CVCL_RS30 (NGPrCARBO5000)
CVCL_RS31 (NGPrCDDP1000)CVCL_RT19 (NGPrDACARB18)CVCL_RS32 (NGPrDOCE20)
CVCL_RS33 (NGPrDOX20)CVCL_RS69 (NGPrETO200)CVCL_RS34 (NGPrETO400)
CVCL_RR55 (NGPrGEMCI20)CVCL_RS70 (NGPrIRINO1000)CVCL_RS71 (NGPrMEL2000)
CVCL_RS35 (NGPrMEL3000)CVCL_RS72 (NGPrMEL4000)CVCL_RS36 (NGPrOXALI4000)
CVCL_RS73 (NGPrPCL20)CVCL_RS37 (NGPrTOPO20)CVCL_RR40 (NGPrVCR10)
CVCL_RR41 (NGPrVCR100)CVCL_RS74 (NGPrVCR20)CVCL_RS75 (NGPrVINB20)
CVCL_RS76 (NGPrVINOR20)
Sex of cell Male
Age at sampling 2Y6M
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001366; DSMZ=ACC-676

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133824,25
D3S135817
D5S81811,12
D7S82011
D8S117911 (DSMZ=ACC-676)
11,12 (DepMap=ACH-001366)
D13S3178,12
D16S5398,11
D18S5115
D19S43313,14
D21S1132,33 (DSMZ=ACC-676)
32,33.1 (DepMap=ACH-001366)
FGA19,23
Penta D8,10 (DepMap=ACH-001366)
10 (DSMZ=ACC-676)
Penta E11,15
TH019
TPOX6,9
vWA16,21

Run an STR similarity search on this cell line
Publications

PubMed=922665; DOI=10.1002/1097-0142(197711)40:5<2256::AID-CNCR2820400536>3.0.CO;2-1
Garrett M. Brodeur, Gurbax Singh Sekhon, Milton N. Goldstein;
Chromosomal aberrations in human neuroblastomas.
Cancer 40:2256-2263(1977)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

PubMed=8490657; DOI=10.1038/ng0193-62
Inge The, Anita E. Murthy, Gregory E. Hannigan, Lee B. Jacoby, Anil G. Menon, James Francis Gusella, Andre Bernards;
Neurofibromatosis type 1 gene mutations in neuroblastoma.
Nat. Genet. 3:62-66(1993)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Nadine Van Roy, Anna Jauch, Mireille Van Gele, Genevieve Laureys, Rogier Versteeg, Anne De Paepe, Thomas Cremer, Frank Speleman;
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11550280; DOI=10.1002/gcc.1174
Nadine Van Roy, Heidi Van Limbergen, Jo Vandesompele, Mireille Van Gele, Bruce Poppe, Helen R. Salwen, Genevieve Laureys, Nunes Manoel, Anne De Paepe, Frank Speleman;
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle ...Show all 18 authors... , Laura Spahn, Shuen-Kuei Liao, Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

Cross-references
Cell line collections (Providers) DSMZ; ACC-676
Cell line databases/resources CLO; CLO_0037091
cancercelllines; CVCL_2141
Cell_Model_Passport; SIDM01785
DepMap; ACH-001366
DSMZCellDive; ACC-676
LINCS_HMS; 51099
LINCS_LDP; LCL-2103
Biological sample resources BioSample; SAMN03473431
Encyclopedic resources Wikidata; Q54930471
Gene expression databases GEO; GSM453633
GEO; GSM692865
GEO; GSM2371249
GEO; GSM2394382
GEO; GSM3145577
GEO; GSM3145726
GEO; GSM4104589
GEO; GSM4104590
GEO; GSM4105333
GEO; GSM4105334
GEO; GSM4105335
GEO; GSM4105336
GEO; GSM4105337
Polymorphism and mutation databases Cosmic; 717421
Cosmic; 923823
Cosmic; 930071
Cosmic; 1019937
Cosmic; 1109120
Cosmic; 1161999
Cosmic; 1167422
Cosmic; 1167988
Cosmic; 1526637
Cosmic; 2058106
Cosmic; 2393638
IARC_TP53; 23601
Progenetix; CVCL_2141
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number33