ID   NGP
AC   CVCL_2141
DR   CLO; CLO_0037091
DR   BioSample; SAMN03473431
DR   cancercelllines; CVCL_2141
DR   Cell_Model_Passport; SIDM01785
DR   Cosmic; 717421
DR   Cosmic; 923823
DR   Cosmic; 930071
DR   Cosmic; 1019937
DR   Cosmic; 1109120
DR   Cosmic; 1161999
DR   Cosmic; 1167422
DR   Cosmic; 1167988
DR   Cosmic; 1526637
DR   Cosmic; 2058106
DR   Cosmic; 2393638
DR   DepMap; ACH-001366
DR   DSMZ; ACC-676
DR   DSMZCellDive; ACC-676
DR   GEO; GSM453633
DR   GEO; GSM692865
DR   GEO; GSM2371249
DR   GEO; GSM2394382
DR   GEO; GSM3145577
DR   GEO; GSM3145726
DR   GEO; GSM4104589
DR   GEO; GSM4104590
DR   GEO; GSM4105333
DR   GEO; GSM4105334
DR   GEO; GSM4105335
DR   GEO; GSM4105336
DR   GEO; GSM4105337
DR   IARC_TP53; 23601
DR   LINCS_HMS; 51099
DR   LINCS_LDP; LCL-2103
DR   Progenetix; CVCL_2141
DR   Wikidata; Q54930471
RX   DOI=10.1007/0-306-46872-7_2;
RX   DOI=10.1016/B978-0-12-008304-6.50015-4;
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   PubMed=922665;
RX   PubMed=6888561;
RX   PubMed=8490657;
RX   PubMed=9283597;
RX   PubMed=11550280;
RX   PubMed=15150091;
RX   PubMed=15892104;
RX   PubMed=16822308;
RX   PubMed=18724359;
RX   PubMed=20655465;
RX   PubMed=22213050;
RX   PubMed=23202128;
RX   PubMed=24466371;
RX   PubMed=28350380;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: ~50-70 hours (DSMZ=ACC-676).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys141Trp (c.423C>G); ClinVar=VCV000376564; Zygosity=Unspecified (DepMap=ACH-001366).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Genomics; ChIP-seq; H3K4me1.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; Chromatin accessibility; ATAC-seq.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
ST   Source(s): DepMap=ACH-001366; DSMZ=ACC-676
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,12
ST   D16S539: 8,11
ST   D18S51: 15
ST   D19S433: 13,14
ST   D21S11: 32,33 (DSMZ=ACC-676)
ST   D21S11: 32,33.1 (DepMap=ACH-001366)
ST   D2S1338: 24,25
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 11 (DSMZ=ACC-676)
ST   D8S1179: 11,12 (DepMap=ACH-001366)
ST   FGA: 19,23
ST   Penta D: 8,10 (DepMap=ACH-001366)
ST   Penta D: 10 (DSMZ=ACC-676)
ST   Penta E: 11,15
ST   TH01: 9
ST   TPOX: 6,9
ST   vWA: 16,21
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   2Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 33
CH   CVCL_HG07 ! N_M5R1
CH   CVCL_HG08 ! N_N20R1
CH   CVCL_0B58 ! NGP-C4
CH   CVCL_AX38 ! NGP.1A.TR1
CH   CVCL_RS68 ! NGPrBORTE20
CH   CVCL_RS30 ! NGPrCARBO5000
CH   CVCL_RS31 ! NGPrCDDP1000
CH   CVCL_RT19 ! NGPrDACARB18
CH   CVCL_RS32 ! NGPrDOCE20
CH   CVCL_RS33 ! NGPrDOX20
CH   CVCL_RS69 ! NGPrETO200
CH   CVCL_RS34 ! NGPrETO400
CH   CVCL_RR55 ! NGPrGEMCI20
CH   CVCL_RS70 ! NGPrIRINO1000
CH   CVCL_RS71 ! NGPrMEL2000
CH   CVCL_RS35 ! NGPrMEL3000
CH   CVCL_RS72 ! NGPrMEL4000
CH   CVCL_RS36 ! NGPrOXALI4000
CH   CVCL_RS73 ! NGPrPCL20
CH   CVCL_RS37 ! NGPrTOPO20
CH   CVCL_RR40 ! NGPrVCR10
CH   CVCL_RR41 ! NGPrVCR100
CH   CVCL_RS74 ! NGPrVCR20
CH   CVCL_RS75 ! NGPrVINB20
CH   CVCL_RS76 ! NGPrVINOR20
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Zehner, Richard
RA   Cinatl, Jaroslaw
RA   Voges, Yvonne
RA   Sharifi, Mohsen
RA   Riecken, Kristoffer
RA   Meyer, Jochen
RA   von Deimling, Andreas
RA   Fichtner, Iduna
RA   Ghafourian, Taravat
RA   Westermann, Frank
RA   Cinatl, Jindrich Jr.
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=11550280; DOI=10.1002/gcc.1174;
RA   Van Roy, Nadine
RA   Van Limbergen, Heidi
RA   Vandesompele, Jo
RA   Van Gele, Mireille
RA   Poppe, Bruce
RA   Salwen, Helen R.
RA   Laureys, Genevieve
RA   Manoel, Nunes
RA   De Paepe, Anne
RA   Speleman, Frank
RT   "Combined M-FISH and CGH analysis allows comprehensive description of
RT   genetic alterations in neuroblastoma cell lines.";
RL   Genes Chromosomes Cancer 32:126-135(2001).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315;
RA   Harenza, Jo Lynne
RA   Diamond, Maura A.
RA   Adams, Rebecca N.
RA   Song, Michael M.
RA   Davidson, Heather L.
RA   Hart, Lori S.
RA   Dent, Maiah H.
RA   Fortina, Paolo
RA   Reynolds, Charles Patrick
RA   Maris, John Matthew
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033.1-170033.8(2017).
//
RX   PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043;
RA   Mosse, Yael P.
RA   Laudenslager, Marci
RA   Longo, Luca
RA   Cole, Kristina A.
RA   Wood, Andrew
RA   Attiyeh, Edward Fathi
RA   Laquaglia, Michael J.
RA   Sennett, Rachel
RA   Lynch, Jill E.
RA   Perri, Patrizia
RA   Laureys, Genevieve
RA   Speleman, Frank
RA   Kim, Cecilia
RA   Hou, Cui-Ping
RA   Hakonarson, Hakon
RA   Torkamani, Ali
RA   Schork, Nicholas Joseph
RA   Brodeur, Garrett M.
RA   Tonini, Gian Paolo
RA   Rappaport, Eric
RA   Devoto, Marcella
RA   Maris, John Matthew
RT   "Identification of ALK as a major familial neuroblastoma
RT   predisposition gene.";
RL   Nature 455:930-935(2008).
//
RX   PubMed=6888561; DOI=10.1038/305245a0;
RA   Schwab, Manfred
RA   Alitalo, Kari
RA   Klempnauer, Karl-Heinz
RA   Varmus, Harold Eliot
RA   Bishop, John Michael
RA   Gilbert, Fred
RA   Brodeur, Garrett M.
RA   Goldstein, Milton Norman
RA   Trent, Jeffrey M.
RT   "Amplified DNA with limited homology to myc cellular oncogene is
RT   shared by human neuroblastoma cell lines and a neuroblastoma tumour.";
RL   Nature 305:245-248(1983).
//
RX   DOI=10.1016/B978-0-12-008304-6.50015-4;
RA   Biedler, June Lee
RA   Meyers, Marian B.
RA   Spengler, Barbara A.
RT   "Homogeneously staining regions and double minute chromosomes,
RT   prevalent cytogenetic abnormalities of human neuroblastoma cells.";
RL   (In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983).
//
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel, Mark A.
RA   Thiele, Carol Jeanne
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele, Carol Jeanne
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027;
RA   Holzel, Michael
RA   Huang, Si-Dong
RA   Koster, Jan
RA   Ora, Ingrid
RA   Lakeman, Arjan
RA   Caron, Huib Nicolaas
RA   Nijkamp, Wouter
RA   Xie, Jing
RA   Callens, Tom
RA   Asgharzadeh, Shahab
RA   Seeger, Robert C.
RA   Messiaen, Ludwine M.
RA   Versteeg, Rogier
RA   Bernards, Rene
RT   "NF1 is a tumor suppressor in neuroblastoma that determines retinoic
RT   acid response and disease outcome.";
RL   Cell 142:218-229(2010).
//
RX   PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7;
RA   Van Roy, Nadine
RA   Jauch, Anna
RA   Van Gele, Mireille
RA   Laureys, Genevieve
RA   Versteeg, Rogier
RA   De Paepe, Anne
RA   Cremer, Thomas
RA   Speleman, Frank
RT   "Comparative genomic hybridization analysis of human neuroblastomas:
RT   detection of distal 1p deletions and further molecular genetic
RT   characterization of neuroblastoma cell lines.";
RL   Cancer Genet. Cytogenet. 97:135-142(1997).
//
RX   PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809;
RA   Schaefer, Karl-Ludwig
RA   Brachwitz, Kristin
RA   Wai, Daniel H.
RA   Braun, Yvonne
RA   Diallo, Raihanatou
RA   Korsching, Eberhard
RA   Eisenacher, Martin
RA   Voss, Reinhard
RA   van Valen, Frans
RA   Baer, Claudia
RA   Selle, Barbara
RA   Spahn, Laura
RA   Liao, Shuen-Kuei
RA   Lee, Kevin A.W.
RA   Hogendoorn, Pancras Cornelis Wilhelmus
RA   Reifenberger, Guido
RA   Gabbert, Helmut Erich
RA   Poremba, Christopher
RT   "Expression profiling of t(12;22) positive clear cell sarcoma of soft
RT   tissue cell lines reveals characteristic up-regulation of potential
RT   new marker genes including ERBB3.";
RL   Cancer Res. 64:3395-3405(2004).
//
RX   PubMed=922665; DOI=10.1002/1097-0142(197711)40:5<2256::AID-CNCR2820400536>3.0.CO;2-1;
RA   Brodeur, Garrett M.
RA   Sekhon, Gurbax Singh
RA   Goldstein, Milton Norman
RT   "Chromosomal aberrations in human neuroblastomas.";
RL   Cancer 40:2256-2263(1977).
//
RX   PubMed=15892104; DOI=10.1002/gcc.20198;
RA   Mosse, Yael P.
RA   Greshock, Joel
RA   Margolin, Adam A.
RA   Naylor, Tara
RA   Cole, Kristina A.
RA   Khazi, Deepa
RA   Hii, George
RA   Winter, Cynthia
RA   Shahzad, Syed
RA   Asziz, Muhammad Usman
RA   Biegel, Jaclyn A.
RA   Weber, Barbara L.
RA   Maris, John Matthew
RT   "High-resolution detection and mapping of genomic DNA alterations in
RT   neuroblastoma.";
RL   Genes Chromosomes Cancer 43:390-403(2005).
//
RX   PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846;
RA   Dam, Vincent
RA   Morgan, Brian T.
RA   Mazanek, Pavel
RA   Hogarty, Michael D.
RT   "Mutations in PIK3CA are infrequent in neuroblastoma.";
RL   BMC Cancer 6:177.1-177.10(2006).
//
RX   PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132;
RA   Gawecka, Joanna E.
RA   Geerts, Dirk
RA   Koster, Jan
RA   Caliva, Maisel J.
RA   Sulzmaier, Florian J.
RA   Opoku-Ansah, John
RA   Wada, Randal K.
RA   Bachmann, Andre S.
RA   Ramos, Joe W.
RT   "PEA15 impairs cell migration and correlates with clinical features
RT   predicting good prognosis in neuroblastoma.";
RL   Int. J. Cancer 131:1556-1568(2012).
//
RX   PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959;
RA   Sausen, Mark
RA   Leary, Rebecca J.
RA   Jones, Sian
RA   Wu, Jian
RA   Reynolds, Charles Patrick
RA   Liu, Xue-Yuan
RA   Blackford, Amanda L.
RA   Parmigiani, Giovanni
RA   Diaz, Luis Alberto Jr.
RA   Papadopoulos, Nickolas
RA   Vogelstein, Bert
RA   Kinzler, Kenneth Wayne
RA   Velculescu, Victor E.
RA   Hogarty, Michael D.
RT   "Integrated genomic analyses identify ARID1A and ARID1B alterations in
RT   the childhood cancer neuroblastoma.";
RL   Nat. Genet. 45:12-17(2013).
//
RX   PubMed=8490657; DOI=10.1038/ng0193-62;
RA   The, Inge
RA   Murthy, Anita E.
RA   Hannigan, Gregory E.
RA   Jacoby, Lee B.
RA   Menon, Anil G.
RA   Gusella, James Francis
RA   Bernards, Andre
RT   "Neurofibromatosis type 1 gene mutations in neuroblastoma.";
RL   Nat. Genet. 3:62-66(1993).
//