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Cellosaurus NCI-H69/CPR (CVCL_2137)

[Text version]
Cell line name NCI-H69/CPR
Synonyms H69/CPR
Accession CVCL_2137
Resource Identification Initiative To cite this cell line use: NCI-H69/CPR (RRID:CVCL_2137)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line

Twentyman P.R., Wright K.A., Mistry P., Kelland L.R., Murrer B.A.
Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin.
Cancer Res. 52:5674-5680(1992)

Cell line collections (Providers) ECACC; 96042328
Cell line databases/resources cancercelllines; CVCL_2137
Encyclopedic resources Wikidata; Q54908104
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21