ID   NCI-H69/CPR
AC   CVCL_2137
SY   H69/CPR
DR   cancercelllines; CVCL_2137
DR   ECACC; 96042328
DR   GEO; GSM1887948
DR   GEO; GSM1888024
DR   Wikidata; Q54908104
RX   PubMed=1327513;
RX   PubMed=27247353;
RX   PubMed=28766886;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
//
RX   PubMed=1327513;
RA   Twentyman P.R., Wright K.A., Mistry P., Kelland L.R., Murrer B.A.;
RT   "Sensitivity to novel platinum compounds of panels of human lung
RT   cancer cell lines with acquired and inherent resistance to
RT   cisplatin.";
RL   Cancer Res. 52:5674-5680(1992).
//
RX   PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282;
RA   Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J.,
RA   Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N.,
RA   Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.;
RT   "Small cell lung cancer screen of oncology drugs, investigational
RT   agents, and gene and microRNA expression.";
RL   J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016).
//
RX   PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882;
RA   Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C.,
RA   Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L.,
RA   Morris J., Evans D.;
RT   "Small cell lung carcinoma cell line screen of etoposide/carboplatin
RT   plus a third agent.";
RL   Cancer Med. 6:1952-1964(2017).
//