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Cellosaurus ELF-153 (CVCL_2031)

[Text version]
Cell line name ELF-153
Synonyms Elf-153; ELF153
Accession CVCL_2031
Resource Identification Initiative To cite this cell line use: ELF-153 (RRID:CVCL_2031)
Comments Part of: LL-100 blood cancer cell line panel.
Characteristics: CSF2 dependent (CelloPub=CLPUB00037; PubMed=7488550).
Doubling time: 36 hours (PubMed=7488550; PubMed=7519473); ~40-60 hours (DSMZ=ACC-693).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
HLA typing Source: DSMZCellDive=ACC-693
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*08:01:01,35:01:01
HLA-CC*07:01:01,07:01:01
Class II
HLA-DPDPA1*01:03:01,02:01:01
DPB1*14:01:01,04:02:01
HLA-DQDQB1*03:01:01,03:01:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*09:01:02,11:01:01
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-693; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10
D1S165615.3,16
D2S44111,14
D2S133818,25
D3S135817,18 (Technion Genomics Center)
18 (DSMZ=ACC-693)
D5S81811
D7S8209,10 (DSMZ=ACC-693)
9.3 (Technion Genomics Center)
D8S117912,13
D10S124813,14
D12S39119
D13S3178
D16S53912,13
D18S5112,15
D19S43313,14.2 (Technion Genomics Center)
13,15 (DSMZ=ACC-693)
D21S1131,32.2
D22S104516
FGA19,23
Penta D12,13
Penta E12,14
TH016,9
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

CLPUB00037
Mathias Freund, Hans-Dieter Kleine, E. Lux, G. Exeriede, Axel-Rainer Hanauske, Hermann Herbst, William Vainchenker, Lothar Schweigerer, Christa Fonatsch, Hubert Poliwoda;
ELF-153: a novel cell line derived from a patient with acute myelofibrosis and AML.
Blut 61:128.232-128.232(1990)

PubMed=7519473; DOI=10.1182/blood.V84.4.1085.1085
Marc-Andre Mouthon, Mathias Freund, Monique Titeux, Andre Katz, Josette Guichard, Janine Breton-Gorius, William Vainchenker;
Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis.
Blood 84:1085-1097(1994)

PubMed=7488550; PMCID=PMC1997200
Hassan Tawhid Hassan, Axel-Rainer Hanauske, E. Lux, Hans-Dieter Kleine, Mathias Freund;
A new fibroblast growth stimulating activity from the human megakaryoblastic leukaemia cell line ELF-153: in vitro and in vivo findings.
Int. J. Exp. Pathol. 76:361-367(1995)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-693
Cell line databases/resources DSMZCellDive; ACC-693
Biological sample resources BioSample; SAMN03473443
Encyclopedic resources Wikidata; Q54832241
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Polymorphism and mutation databases Cosmic; 787427
Cosmic; 975245
Cosmic; 1012064
Cosmic; 1281310
Cosmic; 1465954
Cosmic; 2306197
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number23