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Cellosaurus COV434 (CVCL_2010)

[Text version]
Cell line name COV434
Synonyms COV-434; COV 434
Accession CVCL_2010
Resource Identification Initiative To cite this cell line use: COV434 (RRID:CVCL_2010)
Comments Problematic cell line: Misclassified. Originally thought to be an ovarian granulosa cell tumor but seems to be a small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) (PubMed=33328126).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Because it conserved a number of properties of normal human granulosa cells, it is used in the investigation of such cell type.
Doubling time: 24 hours (PubMed=25984343).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Sequence variations
  • Mutation; HGNC; HGNC:11100; SMARCA4; Simple; c.3952-1G>C; ClinVar=VCV000635379; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=33328126; DepMap=ACH-000123).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:05,31:01
HLA-BB*44:02,50:01
HLA-CC*06:02,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.5
Native American0.68
East Asian, North0.76
East Asian, South0
South Asian0
European, North60.55
European, South36.51
Disease Ovarian small cell carcinoma, hypercalcemic type (NCIt: C40439)
Small cell carcinoma of the ovary (ORDO: Orphanet_370396)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): ECACC=07071909; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,19
D5S81810,11
D7S8208
D8S117913,14
D13S3178,12
D16S5399,12
D18S5110,15
D21S1128
FGA24,25
Penta D10,12
Penta E12
TH019.3
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/cov434/
Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415
Cornelia A.M. van den Berg-Bakker, Anne Hagemeijer, Elsa M. Franken-Postma, Vincent T.H.B.M. Smit, Peter J.K. Kuppen, Hedda H. van Ravenswaay Claasen, Cees J. Cornelisse, Peter I. Schrier;
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.
Int. J. Cancer 53:613-620(1993)

PubMed=9413942; DOI=10.1038/bjc.1997.597; PMCID=PMC2228215
Nathalie Brouwenstijn, Elisabeth H. Slager, Alexander Berthold Hendrik Bakker, Marco W.J. Schreurs, Cory W. van der Spek, Gosse J. Adema, Peter I. Schrier, Carl Gustav Figdor;
Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.
Br. J. Cancer 76:1562-1566(1997)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Jon Christopher Havelock, William E. Rainey, Bruce R. Carr;
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866
Silvia Domcke, Rileen Sinha, Douglas A. Levine, Chris Sander, Nikolaus Schultz;
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126.1-2126.10(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33328126; DOI=10.1016/j.ygyno.2020.12.004; PMCID=PMC10039450
Anthony N. Karnezis, Shary Yu-Ting Chen, Christine Chow, Winnie Yang, William P.D. Hendricks, Pilar Ramos, Natalia Briones, Anne-Marie Mes-Masson, Tjalling Bosse, Cyril Blake Gilks, Jeffrey M. Trent ...Show all 14 authors... , Bernard E. Weissman, David G. Huntsman, Ye-Min Wang; Show fewer authors
Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.
Gynecol. Oncol. 160:568-578(2021)

Cross-references
Cell line collections (Providers) ECACC; 07071909
Cell line databases/resources cancercelllines; CVCL_2010
Cell_Model_Passport; SIDM01476
DepMap; ACH-000123
Biological sample resources BioSample; SAMN03473273
BioSample; SAMN10987973
CRISP screens repositories BioGRID_ORCS_Cell_line; 599
Chemistry resources PharmacoDB; COV434_257_2019
Encyclopedic resources Wikidata; Q54814346
Experimental variables resources EFO; EFO_0006384
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM313704
GEO; GSM886964
GEO; GSM888033
Polymorphism and mutation databases Cosmic; 1149408
Cosmic; 1213590
Cosmic; 1429992
Cosmic; 2368539
Cosmic; 2391829
IARC_TP53; 30027
LiGeA; CCLE_469
Progenetix; CVCL_2010
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34