ID   COV434
AC   CVCL_2010
SY   COV-434; COV 434
DR   EFO; EFO_0006384
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 599
DR   BioSample; SAMN03473273
DR   BioSample; SAMN10987973
DR   cancercelllines; CVCL_2010
DR   Cell_Model_Passport; SIDM01476
DR   Cosmic; 1149408
DR   Cosmic; 1213590
DR   Cosmic; 1429992
DR   Cosmic; 2368539
DR   Cosmic; 2391829
DR   DepMap; ACH-000123
DR   ECACC; 07071909
DR   EGA; EGAS00001000610
DR   GEO; GSM313704
DR   GEO; GSM886964
DR   GEO; GSM888033
DR   IARC_TP53; 30027
DR   LiGeA; CCLE_469
DR   PharmacoDB; COV434_257_2019
DR   Progenetix; CVCL_2010
DR   Wikidata; Q54814346
RX   PubMed=8436435;
RX   PubMed=9413942;
RX   PubMed=15541573;
RX   PubMed=22460905;
RX   PubMed=23839242;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25984343;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=33328126;
WW   https://www.phe-culturecollections.org.uk/media/131227/cov434-cell-line-profile.pdf
CC   Problematic cell line: Misclassified. Originally thought to be an ovarian granulosa cell tumor but seems to be a small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) (PubMed=33328126).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Characteristics: Because it conserved a number of properties of normal human granulosa cells, it is used in the investigation of such cell type.
CC   Doubling time: 24 hours (PubMed=25984343).
CC   HLA typing: A*02:05,31:01; B*44:02,50:01; C*06:02,15:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 11100; SMARCA4; Simple; c.3952-1G>C; ClinVar=VCV000635379; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=33328126; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.5%; Native American=0.68%; East Asian, North=0.76%; East Asian, South=0%; South Asian=0%; European, North=60.55%; European, South=36.51% (PubMed=30894373).
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
ST   Source(s): ECACC; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,12
ST   D16S539: 9,12
ST   D18S51: 10,15
ST   D21S11: 28
ST   D3S1358: 15,19
ST   D5S818: 10,11
ST   D7S820: 8
ST   D8S1179: 13,14
ST   FGA: 24,25
ST   Penta D: 10,12
ST   Penta E: 12
ST   TH01: 9.3
ST   TPOX: 9,11
ST   vWA: 16,18
DI   NCIt; C40439; Ovarian small cell carcinoma, hypercalcemic type
DI   ORDO; Orphanet_370396; Small cell carcinoma of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   26Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 31
//
RX   PubMed=8436435; DOI=10.1002/ijc.2910530415;
RA   van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M.,
RA   Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H.,
RA   Cornelisse C.J., Schrier P.I.;
RT   "Establishment and characterization of 7 ovarian carcinoma cell lines
RT   and one granulosa tumor cell line: growth features and cytogenetics.";
RL   Int. J. Cancer 53:613-620(1993).
//
RX   PubMed=9413942; DOI=10.1038/bjc.1997.597;
RA   Brouwenstijn N., Slager E.H., Bakker A.B.H., Schreurs M.W.J.,
RA   van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.;
RT   "Transcription of the gene encoding melanoma-associated antigen gp100
RT   in tissues and cell lines other than those of the melanocytic
RT   lineage.";
RL   Br. J. Cancer 76:1562-1566(1997).
//
RX   PubMed=15541573; DOI=10.1016/j.mce.2004.04.018;
RA   Havelock J.C., Rainey W.E., Carr B.R.;
RT   "Ovarian granulosa cell lines.";
RL   Mol. Cell. Endocrinol. 228:67-78(2004).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23839242; DOI=10.1038/ncomms3126;
RA   Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.;
RT   "Evaluating cell lines as tumour models by comparison of genomic
RT   profiles.";
RL   Nat. Commun. 4:2126.1-2126.10(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=33328126; DOI=10.1016/j.ygyno.2020.12.004;
RA   Karnezis A.N., Chen S.Y.-T., Chow C., Yang W., Hendricks W.P.D.,
RA   Ramos P., Briones N., Mes-Masson A.-M., Bosse T., Gilks C.B.,
RA   Trent J.M., Weissman B.E., Huntsman D.G., Wang Y.-M.;
RT   "Re-assigning the histologic identities of COV434 and TOV-112D ovarian
RT   cancer cell lines.";
RL   Gynecol. Oncol. 160:568-578(2021).
//