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Cellosaurus PC-MDS (CVCL_1Q81)

[Text version]
Cell line name PC-MDS
Accession CVCL_1Q81
Resource Identification Initiative To cite this cell line use: PC-MDS (RRID:CVCL_1Q81)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=19344951).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00379.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=17350682; DOI=10.1016/j.leukres.2007.01.012
Bogdanovic G., Jurisic V., Kraguljac N., Mrdjanovic J., Jakimov D., Krtolica K., Krajnovic M., Magic Z., Stojiljkovic B., Andrijevic L., Srdic-Rajic T., Baltic M., Popovic S.
Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome.
Leuk. Res. 31:1097-1105(2007)

PubMed=17917092; DOI=10.1007/s12032-007-0031-y
Bogdanovic G., Jakimov D., Stojiljkovic B., Jurisic V.
The cell growth, morphology and immunocytochemistry of novel cell line established from a bone marrow of the patient with therapy-related myelodysplastic syndrome, entitled PC-MDS.
Med. Oncol. 24:419-424(2007)

PubMed=19344951; DOI=10.1016/j.leukres.2009.03.005
Drexler H.G., Dirks W.G., MacLeod R.A.F.
Many are called MDS cell lines: one is chosen.
Leuk. Res. 33:1011-1016(2009)

Biological sample resources BioSample; SAMN03151810
Encyclopedic resources Wikidata; Q54938512
Entry history
Entry creation08-Jul-2015
Last entry update02-May-2024
Version number20