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Cellosaurus MDA-MB-231-luc2-tdTomato-LN (CVCL_1E88)

[Text version]
Cell line name MDA-MB-231-luc2-tdTomato-LN
Accession CVCL_1E88
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc2-tdTomato-LN (RRID:CVCL_1E88)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase (Note=With optimized codon usage for mammalian expression).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D90 (MDA-MB-231-luc2-tdTomato)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

DOI=10.1158/1538-7445.AM2013-3908
Kim J.-B., Wong K., Urban K.
Generation of invasive breast cancer cell lines for in vivo imaging.
Cancer Res. 73 Suppl. 8:3908-3908(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1E88
Encyclopedic resources Wikidata; Q54904604
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number22