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Cellosaurus MDA-MB-231-luc-D3H1 (CVCL_1D88)

[Text version]
Cell line name MDA-MB-231-luc-D3H1
Synonyms D3H1
Accession CVCL_1D88
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc-D3H1 (RRID:CVCL_1D88)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Expression of firefly luciferase is under the control of a SV40 promoter (PerkinElmer=119261).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
CVCL_D257 (MDA-MB-231-luc-D3H2LN)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=15987449; DOI=10.1186/bcr1026
Jenkins D.E., Hornig Y.S., Oei Y.A., Dusich J.M., Purchio T.
Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice.
Breast Cancer Res. 7:R444-R454(2005)

Cell line collections (Providers) PerkinElmer; 119261 - Discontinued
Cell line databases/resources cancercelllines; CVCL_1D88
Encyclopedic resources Wikidata; Q54904598
Entry history
Entry creation08-Jul-2015
Last entry update30-Jan-2024
Version number19