| Cell line name |
MCF-7/164R-5 |
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| Synonyms |
MCF7/164R-5; MCF-7/164(R)-5; 164R-5 |
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| Accession |
CVCL_1D38 |
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| Resource Identification Initiative |
To cite this cell line use: MCF-7/164R-5 (RRID:CVCL_1D38) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1D47 (MCF-7/S0.5) |
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=7759159; DOI=10.1002/ijc.2910610417
Anne E. Lykkesfeldt, Soren S. Larsen, Per Briand;
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment.
Int. J. Cancer 61:529-534(1995) PubMed=16172194; DOI=10.1677/erc.1.00946
Thomas Frogne, Jan Stenvang Jepsen, Soren S. Larsen, Cathrine Kolster Fog, Bettina Lundin Brockdorff, Anne E. Lykkesfeldt;
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005) PubMed=25362855; DOI=10.1038/onc.2014.351
Susan Thrane, Astrid M. Pedersen, Mathilde Borg Houlberg Thomsen, Tove Kirkegaard, Birgitte Bruun Rasmussen, Anne Katrine Duun-Henriksen, Anne-Vibeke Laenkholm, Martin Bak, Anne E. Lykkesfeldt, Christina Westmose Yde;
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015) |
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| Cross-references |
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| Cell line collections (Providers) |
CancerTools; 152102
Ximbio; 152102
|
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| Cell line databases/resources |
cancercelllines; CVCL_1D38
|
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| Encyclopedic resources |
Wikidata; Q54904340
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| Entry history |
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| Entry creation | 08-Jul-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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