ID   MCF-7/164R-5
AC   CVCL_1D38
SY   MCF7/164R-5; MCF-7/164(R)-5; 164R-5
DR   cancercelllines; CVCL_1D38
DR   CancerTools; 152102
DR   Wikidata; Q54904340
DR   Ximbio; 152102
RX   PubMed=7759159;
RX   PubMed=16172194;
RX   PubMed=25362855;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1D47 ! MCF-7/S0.5
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 17
//
RX   PubMed=25362855; DOI=10.1038/onc.2014.351;
RA   Thrane, Susan
RA   Pedersen, Astrid M.
RA   Thomsen, Mathilde Borg Houlberg
RA   Kirkegaard, Tove
RA   Rasmussen, Birgitte Bruun
RA   Duun-Henriksen, Anne Katrine
RA   Laenkholm, Anne-Vibeke
RA   Bak, Martin
RA   Lykkesfeldt, Anne E.
RA   Yde, Christina Westmose
RT   "A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as
RT   novel treatment targets in antiestrogen-resistant breast cancer
RT   cells.";
RL   Oncogene 34:4199-4210(2015).
//
RX   PubMed=7759159; DOI=10.1002/ijc.2910610417;
RA   Lykkesfeldt, Anne E.
RA   Larsen, Soren S.
RA   Briand, Per
RT   "Human breast cancer cell lines resistant to pure anti-estrogens are
RT   sensitive to tamoxifen treatment.";
RL   Int. J. Cancer 61:529-534(1995).
//
RX   PubMed=16172194; DOI=10.1677/erc.1.00946;
RA   Frogne, Thomas
RA   Jepsen, Jan Stenvang
RA   Larsen, Soren S.
RA   Fog, Cathrine Kolster
RA   Brockdorff, Bettina Lundin
RA   Lykkesfeldt, Anne E.
RT   "Antiestrogen-resistant human breast cancer cells require activated
RT   protein kinase B/Akt for growth.";
RL   Endocr. Relat. Cancer 12:599-614(2005).
//