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Cellosaurus HROBML03 (CVCL_1D09)

[Text version]
Cell line name HROBML03
Accession CVCL_1D09
Resource Identification Initiative To cite this cell line use: HROBML03 (RRID:CVCL_1D09)
Comments Problematic cell line: Contaminated. The STR profile is identical to that of the NCI-H460 cell line. Contamination confirmed by personal communication of Linnebacher M. Originally thought to originate from the resection of the brain metastasis of a 47 year old female Caucasian patient with a non-small cell lung carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00587.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CLS

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165611,14.3
D2S133817,25
D3S135815,18
D5S8189,10
D6S104311,14
D7S8209,12
D8S117912
D12S39121
D13S31713
D16S5399
D18S5113,15
D19S43314
D21S1130
FGA21,23
Penta D11,13
Penta E5
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=25069049; DOI=10.1016/j.bcp.2014.07.014
Haustein M., Ramer R., Linnebacher M., Manda K., Hinz B.
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.
Biochem. Pharmacol. 92:312-325(2014)

Cross-references
Cell line collections CLS; 300801 - Discontinued
Encyclopedic resources Wikidata; Q54895235
Entry history
Entry creation08-Jul-2015
Last entry update21-Mar-2023
Version number17