AC   CVCL_1D09
DR   cancercelllines; CVCL_1D09
DR   CLS; 300801
DR   Wikidata; Q54895235
RX   PubMed=25069049;
CC   Problematic cell line: Contaminated. The STR profile is identical to that of the NCI-H460 cell line. Contamination confirmed by personal communication of Linnebacher M. Originally thought to originate from the resection of the brain metastasis of a 47 year old female Caucasian patient with a non-small cell lung carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00587.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: CLS; 300801; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): CLS=300801
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D12S391: 21
ST   D13S317: 13
ST   D16S539: 9
ST   D18S51: 13,15
ST   D19S433: 14
ST   D1S1656: 11,14.3
ST   D21S11: 30
ST   D2S1338: 17,25
ST   D3S1358: 15,18
ST   D5S818: 9,10
ST   D6S1043: 11,14
ST   D7S820: 9,12
ST   D8S1179: 12
ST   FGA: 21,23
ST   Penta D: 11,13
ST   Penta E: 5
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 02-05-24; Version: 20
RX   PubMed=25069049; DOI=10.1016/j.bcp.2014.07.014;
RA   Haustein M., Ramer R., Linnebacher M., Manda K., Hinz B.;
RT   "Cannabinoids increase lung cancer cell lysis by lymphokine-activated
RT   killer cells via upregulation of ICAM-1.";
RL   Biochem. Pharmacol. 92:312-325(2014).