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Cellosaurus HROC32 (CVCL_1D06)

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Cell line name HROC32
Synonyms HROC32P
Accession CVCL_1D06
Resource Identification Initiative To cite this cell line use: HROC32 (RRID:CVCL_1D06)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Doubling time: 32 +- 10.6 hours (PubMed=25574089); 30 hours (CLS=300818).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (CLS=300818).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (CLS=300818).
HLA typing Source: CLS=300818
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,03:01
HLA-CC*07:01,14:02
Class II
HLA-DPDPB1*01:01,02:01
HLA-DQDQA1*01:02,05:01
DQB1*02:01,03:01
HLA-DRDRB1*03:01,11:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YD55 ! B-LCL-HROC32
CVCL_1D07 ! HROC32 T3 M1
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): CLS=300818; Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX
CSF1PO14
D3S135815,17
D5S81811,12 (CLS=300818; Direct_author_submission)
12 (PubMed=25926053)
D7S8208,11
D8S117912
D13S31711,12 (Direct_author_submission)
12 (CLS=300818; PubMed=25926053)
D16S53911,12
D18S5112
D21S1131
FGA18,19
Penta D12
Penta E10
TH018,9
TPOX8,11
vWA19

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Publications

PubMed=25574089; DOI=10.3748/wjg.v21.i1.164; PMCID=PMC4284332
Claudia Maletzki, Michael Gock, Martin Randow, Ernst Klar, Maja Huhns, Friedrich Prall, Michael Linnebacher;
Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
World J. Gastroenterol. 21:164-176(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Christina Susanne Mullins, Bianca Micheel, Stephanie Matschos, Matthias Leuchter, Florian Burtin, Mathias Krohn, Maja Huhns, Ernst Klar, Friedrich Prall, Michael Linnebacher;
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300818
Cell line databases/resources cancercelllines; CVCL_1D06
Encyclopedic resources Wikidata; Q54895282
Gene expression databases GEO; GSM1448079
Polymorphism and mutation databases Cosmic; 2324290
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number24