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Cellosaurus COLO 206F (CVCL_1988)

[Text version]
Cell line name COLO 206F
Synonyms Colo-206F; COLO-206F; Colo 206F; COLO206F; COLO 206; COLO206; Colorado 206F
Accession CVCL_1988
Resource Identification Initiative To cite this cell line use: COLO 206F (RRID:CVCL_1988)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: ~2-3 days (DSMZ=ACC-21).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*07:02,08:01
HLA-CC*07:01,07:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4V92 (COLO206F-AR)
Originate from same individual CVCL_9976 ! COLO 197
CVCL_9977 ! COLO 200
CVCL_1987 ! COLO 201
CVCL_0218 ! COLO 205
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D2S133817,18
D3S135816
D5S81810,13
D7S8209,10
D8S11799,14
D13S31710,12
D16S53912,13
D18S5118
D19S43313,14
D21S1130.2,33.2
FGA21,23
Penta D9,11
Penta E13,15
TH018,9
TPOX11
vWA15

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=6277475
Frampton R.J., Suva L.J., Eisman J.A., Findlay D.M., Moore G.E., Moseley J.M., Martin T.J.
Presence of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture.
Cancer Res. 42:1116-1119(1982)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=10051639; DOI=10.1073/pnas.96.5.2316
Efstathiou J.A., Liu D., Wheeler J.M., Kim H.C., Beck N.E., Ilyas M., Karayiannakis A.J., Mortensen N.J., Kmiot W., Playford R.J., Pignatelli M., Bodmer W.F.
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
Proc. Natl. Acad. Sci. U.S.A. 96:2316-2321(1999)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) DSMZ; ACC-21
ECACC; 93052620
Cell line databases/resources CLO; CLO_0002570
CLDB; cl864
cancercelllines; CVCL_1988
Cell_Model_Passport; SIDM00822
ColonAtlas; COLO206F
DSMZCellDive; ACC-21
LINCS_LDP; LCL-1159
Anatomy/cell type resources BTO; BTO:0002199
Chemistry resources PharmacoDB; COLO206F_215_2019
Encyclopedic resources Wikidata; Q54814077
Experimental variables resources EFO; EFO_0006554
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206460
GEO; GSM274776
GEO; GSM513935
GEO; GSM514188
GEO; GSM784009
GEO; GSM1374453
Polymorphism and mutation databases Cosmic; 2760082
Progenetix; CVCL_1988
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number33