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Cellosaurus OCI-Ly1 (CVCL_1879)

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Cell line name OCI-Ly1
Synonyms OCI-LY1; OCI-ly1; OCI-LY-1; OCI-Ly-1; Oci-Ly-1; OCI-Ly 1; OCI-Ly01; OCI Ly1; Ly1; LY1
Accession CVCL_1879
Resource Identification Initiative To cite this cell line use: OCI-Ly1 (RRID:CVCL_1879)
Comments From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~50-60 hours (DSMZ=ACC-722).
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: Ocl-Ly1; GEO=GSM3150250.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01
HLA-CC*05:01,05:01
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-722

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133821,24
D3S135816,17
D5S81811,12
D7S82011
D8S11798,15
D13S31712
D16S5399
D18S5112
D19S43313,15
D21S1129,30
FGA21,22
Penta D9,11
Penta E7,10
TH019.3
TPOX8,9
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307
Mary Elizabeth Tweeddale, Bing Lim, Nazir Jamal, Jean Robinson, John Raymond Zalcberg, Gina Lockwood, Mark David Minden, Hans August Messner;
The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.
Blood 69:1307-1314(1987)

PubMed=8574164; DOI=10.3109/10428199509059672
Hong Chang, John A. Blondal, Sam Benchimol, Mark David Minden, Hans August Messner;
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
Leuk. Lymphoma 19:165-171(1995)

PubMed=10676951; DOI=10.1038/35000501
Ash Arash Alizadeh, Michael Bruce Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer Connolly Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I. Powell ...Show all 31 authors... , Li-Ming Yang, Gerald E. Marti, Troy Moore, James Hudson Jr., Li-Sheng Lu, David B. Lewis, Robert Tibshirani, Gavin Sherlock, Wing-Chung Chan, Timothy Charles Greiner, Dennis D. Weisenburger, James Olen Armitage, Roger Allen Warnke, Ronald Levy, Wyndham H. Wilson, Michael Rhodes Grever, John C. Byrd, David Botstein, Patrick O'Reilly Brown, Louis Michael Staudt; Show fewer authors
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Nature 403:503-511(2000)

PubMed=11807979; DOI=10.1002/gcc.10025
Sukvarsha Mehra, Hans August Messner, Mark David Minden, Raju S.K. Chaganti;
Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines.
Genes Chromosomes Cancer 33:225-234(2002)

PubMed=12169673; DOI=10.1016/S1525-1578(10)60693-9; PMCID=PMC1906980
Ryan S. Robetorye, Sandra Dawn Bohling, John W. Morgan, G. Chris Fillmore, Megan S. Lim, Kojo Seys John Elenitoba-Johnson;
Microarray analysis of B-cell lymphoma cell lines with the t(14;18).
J. Mol. Diagn. 4:123-136(2002)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058
Cheng Li, Sang-Woo Kim, Deepak Rai, Aswani R. Bolla, Siddharth Adhvaryu, Marsha C. Kinney, Ryan S. Robetorye, Ricardo C.T. Aguiar;
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer ...Show all 14 authors... , Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov, Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=23699601; DOI=10.1182/blood-2013-02-483727; PMCID=PMC3744992
Ryan D. Morin, Karen Mungall, Erin D. Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, Jia-Rui Ding, Andrew Roth, Readman Chiu, Richard D. Corbett ...Show all 34 authors... , Fong Chun Chan, Maria Mendez-Lago, Diane L. Trinh, Madison Bolger-Munro, Greg Taylor, Alireza Hadj Khodabakhshi, Susana Ben-Neriah, Julia Pon, Barbara Meissner, Bruce W. Woolcock, Noushin Farnoud, Sanja Rogic, Emilia L. Lim, Nathalie A. Johnson, Sohrab P. Shah, Steven J.M. Jones, Christian Steidl, Robert A. Holt, Inanc Birol, Richard Moore, Joseph M. Connors, Randy D. Gascoyne, Marco Antonio Marra; Show fewer authors
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.
Blood 122:1256-1265(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-722
Cell line databases/resources cancercelllines; CVCL_1879
DSMZCellDive; ACC-722
Lonza; 1352
Biological sample resources ENCODE; ENCBS397COL
ENCODE; ENCBS729LWO
ENCODE; ENCBS899DSB
ENCODE; ENCBS945KYE
CRISP screens repositories BioGRID_ORCS_Cell_line; 1211
Chemistry resources ChEMBL-Cells; CHEMBL4295427
ChEMBL-Targets; CHEMBL4296480
PubChem_Cell_line; CVCL_1879
Encyclopedic resources Wikidata; Q54931759
Experimental variables resources EFO; EFO_0005907
Gene expression databases GEO; GSM1957
GEO; GSM380130
GEO; GSM552450
GEO; GSM1035341
GEO; GSM1059803
GEO; GSM1374783
GEO; GSM3150250
Polymorphism and mutation databases Cosmic; 1134602
Cosmic; 1295512
Cosmic; 1329091
Cosmic; 1517641
Cosmic; 1541900
Cosmic; 1629932
Cosmic; 1636682
Cosmic; 1945183
Cosmic; 2276318
Progenetix; CVCL_1879
Proteomic databases PRIDE; PXD012087
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32