ID   OCI-Ly1
AC   CVCL_1879
SY   OCI-LY1; OCI-ly1; OCI-LY-1; OCI-Ly-1; Oci-Ly-1; OCI-Ly 1; OCI-Ly01; OCI Ly1; Ly1; LY1
DR   EFO; EFO_0005907
DR   BioGRID_ORCS_Cell_line; 1211
DR   cancercelllines; CVCL_1879
DR   ChEMBL-Cells; CHEMBL4295427
DR   ChEMBL-Targets; CHEMBL4296480
DR   Cosmic; 1134602
DR   Cosmic; 1295512
DR   Cosmic; 1329091
DR   Cosmic; 1517641
DR   Cosmic; 1541900
DR   Cosmic; 1629932
DR   Cosmic; 1636682
DR   Cosmic; 1945183
DR   Cosmic; 2276318
DR   DSMZ; ACC-722
DR   DSMZCellDive; ACC-722
DR   ENCODE; ENCBS397COL
DR   ENCODE; ENCBS729LWO
DR   ENCODE; ENCBS899DSB
DR   ENCODE; ENCBS945KYE
DR   GEO; GSM1957
DR   GEO; GSM380130
DR   GEO; GSM552450
DR   GEO; GSM1035341
DR   GEO; GSM1059803
DR   GEO; GSM1374783
DR   GEO; GSM3150250
DR   Lonza; 1352
DR   PRIDE; PXD012087
DR   Progenetix; CVCL_1879
DR   PubChem_Cell_line; CVCL_1879
DR   Wikidata; Q54931759
RX   PubMed=3567358;
RX   PubMed=8574164;
RX   PubMed=10676951;
RX   PubMed=11807979;
RX   PubMed=12169673;
RX   PubMed=19278952;
RX   PubMed=19358282;
RX   PubMed=20628145;
RX   PubMed=23257783;
RX   PubMed=23292937;
RX   PubMed=23699601;
RX   PubMed=25960936;
CC   From: Ontario Cancer Institute (OCI); Toronto; Canada.
CC   Doubling time: ~50-60 hours (DSMZ=ACC-722).
CC   HLA typing: A*02:01; C*05:01,05:01 (PubMed=25960936).
CC   Omics: Genomics; ChIP-seq; H3K9ac.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Misspelling: Ocl-Ly1; GEO=GSM3150250.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-722
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 9
ST   D18S51: 12
ST   D19S433: 13,15
ST   D21S11: 29,30
ST   D2S1338: 21,24
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 8,15
ST   FGA: 21,22
ST   Penta D: 9,11
ST   Penta E: 7,10
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 15,16
DI   NCIt; C8851; Diffuse large B-cell lymphoma
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356;
RA   Green, Michael Richard
RA   Monti, Stefano
RA   Rodig, Scott J.
RA   Juszczynski, Przemyslaw
RA   Currie, Treeve
RA   O'Donnell, Evan
RA   Chapuy, Bjoern
RA   Takeyama, Kunihiko
RA   Neuberg, Donna
RA   Golub, Todd Robert
RA   Kutok, Jeffery L.
RA   Shipp, Margaret Ann
RT   "Integrative analysis reveals selective 9p24.1 amplification,
RT   increased PD-1 ligand expression, and further induction via JAK2 in
RT   nodular sclerosing Hodgkin lymphoma and primary mediastinal large
RT   B-cell lymphoma.";
RL   Blood 116:3268-3277(2010).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051;
RA   Zhang, Jenny
RA   Grubor, Vladimir
RA   Love, Cassandra L.
RA   Banerjee, Anjishnu
RA   Richards, Kristy L.
RA   Mieczkowski, Piotr Andrzej
RA   Dunphy, Cherie
RA   Choi, William Wai-Lap
RA   Au, Wing Yan
RA   Srivastava, Gopesh
RA   Lugar, Patricia Lynne
RA   Rizzieri, David A.
RA   Lagoo, Anand S.
RA   Bernal-Mizrachi, Leon
RA   Mann, Karen P.
RA   Flowers, Christopher Robert
RA   Naresh, Kikkeri N.
RA   Evens, Andrew M.
RA   Gordon, Leo I.
RA   Czader, Magdalena Beata
RA   Gill, Javed Iqbal
RA   Hsi, Eric Darryl
RA   Liu, Qing-Quan
RA   Fan, Alice
RA   Walsh, Katherine
RA   Jima, Dereje
RA   Smith, Lisa L.
RA   Johnson, Amy J.
RA   Byrd, John C.
RA   Luftig, Micah Alan
RA   Ni, Ting
RA   Zhu, Jun
RA   Chadburn, Amy
RA   Levy, Shawn
RA   Dunson, David Brian
RA   Dave, Sandeep S.
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=19358282; DOI=10.1002/ijc.24351;
RA   Inagaki, Atsushi
RA   Ishida, Takashi
RA   Yano, Hiroki
RA   Ishii, Toshihiko
RA   Kusumoto, Shigeru
RA   Ito, Asahi
RA   Ri, Masaki
RA   Mori, Fumiko
RA   Ding, Jian-Min
RA   Komatsu, Hirokazu
RA   Iida, Shinsuke
RA   Ueda, Ryuzo
RT   "Expression of the ULBP ligands for NKG2D by B-NHL cells plays an
RT   important role in determining their susceptibility to
RT   rituximab-induced ADCC.";
RL   Int. J. Cancer 125:212-221(2009).
//
RX   PubMed=23257783; DOI=10.1038/leu.2012.367;
RA   Wenzel, Soren-Sebastian
RA   Grau, Michael
RA   Mavis, Cory
RA   Hailfinger, Stephan
RA   Wolf, Annette
RA   Madle, Hannelore
RA   Deeb, George
RA   Dorken, Bernd
RA   Thome, Margot
RA   Lenz, Peter
RA   Dirnhofer, Stefan
RA   Hernandez-Ilizaliturri, Francisco Javier
RA   Tzankov, Alexandar
RA   Lenz, Georg
RT   "MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.";
RL   Leukemia 27:1381-1390(2013).
//
RX   PubMed=8574164; DOI=10.3109/10428199509059672;
RA   Chang, Hong
RA   Blondal, John A.
RA   Benchimol, Sam
RA   Minden, Mark David
RA   Messner, Hans August
RT   "p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's
RT   lymphoma cell lines.";
RL   Leuk. Lymphoma 19:165-171(1995).
//
RX   PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058;
RA   Li, Cheng
RA   Kim, Sang-Woo
RA   Rai, Deepak
RA   Bolla, Aswani R.
RA   Adhvaryu, Siddharth
RA   Kinney, Marsha C.
RA   Robetorye, Ryan S.
RA   Aguiar, Ricardo C.T.
RT   "Copy number abnormalities, MYC activity, and the genetic fingerprint
RT   of normal B cells mechanistically define the microRNA profile of
RT   diffuse large B-cell lymphoma.";
RL   Blood 113:6681-6690(2009).
//
RX   PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307;
RA   Tweeddale, Mary Elizabeth
RA   Lim, Bing
RA   Jamal, Nazir
RA   Robinson, Jean
RA   Zalcberg, John Raymond
RA   Lockwood, Gina
RA   Minden, Mark David
RA   Messner, Hans August
RT   "The presence of clonogenic cells in high-grade malignant lymphoma: a
RT   prognostic factor.";
RL   Blood 69:1307-1314(1987).
//
RX   PubMed=10676951; DOI=10.1038/35000501;
RA   Alizadeh, Ash Arash
RA   Eisen, Michael Bruce
RA   Davis, R. Eric
RA   Ma, Chi
RA   Lossos, Izidore S.
RA   Rosenwald, Andreas
RA   Boldrick, Jennifer Connolly
RA   Sabet, Hajeer
RA   Tran, Truc
RA   Yu, Xin
RA   Powell, John I.
RA   Yang, Li-Ming
RA   Marti, Gerald E.
RA   Moore, Troy
RA   Hudson, James Jr.
RA   Lu, Li-Sheng
RA   Lewis, David B.
RA   Tibshirani, Robert John
RA   Sherlock, Gavin
RA   Chan, Wing-Chung
RA   Greiner, Timothy Charles
RA   Weisenburger, Dennis D.
RA   Armitage, James Olen
RA   Warnke, Roger Allen
RA   Levy, Ronald
RA   Wilson, Wyndham H.
RA   Grever, Michael Rhodes
RA   Byrd, John C.
RA   Botstein, David
RA   Brown, Patrick O'Reilly
RA   Staudt, Louis Michael
RT   "Distinct types of diffuse large B-cell lymphoma identified by gene
RT   expression profiling.";
RL   Nature 403:503-511(2000).
//
RX   PubMed=12169673; DOI=10.1016/S1525-1578(10)60693-9; PMCID=PMC1906980;
RA   Robetorye, Ryan S.
RA   Bohling, Sandra Dawn
RA   Morgan, John W.
RA   Fillmore, G. Chris
RA   Lim, Megan S.
RA   Elenitoba-Johnson, Kojo Seys John
RT   "Microarray analysis of B-cell lymphoma cell lines with the
RT   t(14;18).";
RL   J. Mol. Diagn. 4:123-136(2002).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=23699601; DOI=10.1182/blood-2013-02-483727; PMCID=PMC3744992;
RA   Morin, Ryan D.
RA   Mungall, Karen
RA   Pleasance, Erin D.
RA   Mungall, Andrew J.
RA   Goya, Rodrigo
RA   Huff, Ryan D.
RA   Scott, David W.
RA   Ding, Jia-Rui
RA   Roth, Andrew
RA   Chiu, Readman
RA   Corbett, Richard D.
RA   Chan, Fong Chun
RA   Mendez-Lago, Maria
RA   Trinh, Diane L.
RA   Bolger-Munro, Madison
RA   Taylor, Greg
RA   Hadj Khodabakhshi, Alireza
RA   Ben-Neriah, Susana
RA   Pon, Julia
RA   Meissner, Barbara
RA   Woolcock, Bruce W.
RA   Farnoud, Noushin
RA   Rogic, Sanja
RA   Lim, Emilia L.
RA   Johnson, Nathalie A.
RA   Shah, Sohrab P.
RA   Jones, Steven J.M.
RA   Steidl, Christian
RA   Holt, Robert A.
RA   Birol, Inanc
RA   Moore, Richard
RA   Connors, Joseph M.
RA   Gascoyne, Randy D.
RA   Marra, Marco Antonio
RT   "Mutational and structural analysis of diffuse large B-cell lymphoma
RT   using whole-genome sequencing.";
RL   Blood 122:1256-1265(2013).
//
RX   PubMed=11807979; DOI=10.1002/gcc.10025;
RA   Mehra, Sukvarsha
RA   Messner, Hans August
RA   Minden, Mark David
RA   Chaganti, Raju S.K.
RT   "Molecular cytogenetic characterization of non-Hodgkin lymphoma cell
RT   lines.";
RL   Genes Chromosomes Cancer 33:225-234(2002).
//