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Cellosaurus Mino (CVCL_1872)

[Text version]
Cell line name Mino
Synonyms MINO
Accession CVCL_1872
Resource Identification Initiative To cite this cell line use: Mino (RRID:CVCL_1872)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 72 hours (PubMed=25315077); ~50 hours (DSMZ=ACC-687).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu88Lys (c.262G>A); ClinVar=VCV000821566; Zygosity=Homozygous (DepMap=ACH-000220).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000013901; Zygosity=Heterozygous (DepMap=ACH-000220).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val147Gly (c.440T>G); Zygosity=Homozygous (DepMap=ACH-000220).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*11:01,68:01
HLA-BB*35:01,39:01
HLA-CC*04:01,12:03
Class II
HLA-DQDQA1*01:02,01:02
DQB1*05:01,06:03
HLA-DRDRB1*01:01,13:01

Source: PubMed=25688540
Class I
HLA-AA*11,68
HLA-BB*35,39
HLA-CC*04,12

Source: DSMZCellDive=ACC-687
Class I
HLA-AA*11:01:01,68:01:01
HLA-BB*35:01:01,39:01:01
HLA-CC*04:01:01,12:03:01
Class II
HLA-DPDPA1*01:03:01,02:01:01
DPB1*10:01:01,10:01:01
HLA-DQDQA1*01:03:01,01:01:01
DQB1*05:01:01,06:03:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*01:01:01,13:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.85
Native American0
East Asian, North1.5
East Asian, South0
South Asian6.1
European, North39.56
European, South51.98
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003033/4947; ATCC=CRL-3000; DSMZ=ACC-687

Markers:
AmelogeninX,Y
CSF1PO9,11
D2S133823
D3S135818
D5S81811,12
D7S82010,11
D8S117913
D13S31712
D16S53911,12
D18S5112,14
D19S43315
D21S1129,30
FGA23,25
Penta D12,13
Penta E5,17
TH019.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=12127561; DOI=10.1016/S0145-2126(02)00013-9
Raymond Lai, Timothy J. McDonnell, Sean L. O'Connor, L. Jeffrey Medeiros, Raida I. Oudat, Michael J. Keating, Myra B. Morgan, Tyler Jay Curiel, Richard Joseph Ford Jr.;
Establishment and characterization of a new mantle cell lymphoma cell line, Mino.
Leuk. Res. 26:849-855(2002)

PubMed=12683869; DOI=10.5858/2003-127-0424-COMCLC
Hesham M. Amin, Timothy J. McDonnell, L. Jeffrey Medeiros, Georgios Z. Rassidakis, Vasiliki Leventaki, Sean L. O'Connor, Michael J. Keating, Raymond Lai;
Characterization of 4 mantle cell lymphoma cell lines. Establishment of an in vitro study model.
Arch. Pathol. Lab. Med. 127:424-431(2003)

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731
Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A. Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L. Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J. Calasanz ...Show all 18 authors... , Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S. Lossos, Miguel Angel Piris, Martin E. Fernandez-Zapico, Jose Angel Martinez-Climent; Show fewer authors
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24362935; DOI=10.1038/nm.3435
Rami Rahal, Mareike Frick, Rodrigo Romero, Joshua M. Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Carrie Bhang, David A. Ruddy, Audrey Kauffmann, Ali Farsidjani ...Show all 30 authors... , Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Dorken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John E. Monahan, Michael P. Morrissey, Christine Fritsch, William Raj Sellers, Vesselina G. Cooke, Randy D. Gascoyne, Georg Lenz, Frank Stegmeier; Show fewer authors
Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
Nat. Med. 20:87-92(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25315077; DOI=10.3109/10428194.2014.970548
Laura K. Fogli, Michael E. Williams, Joseph M. Connors, Yvonne A. Reid, Kathleen Brown, Owen A. O'Connor;
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
Leuk. Lymphoma 56:2114-2122(2015)

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145
Su-Bing Cao, Michael J. Strong, Xia Wang, Walter N. Moss, Monica Concha, Zhen Lin, Tina O'Grady, Melody Baddoo, Claire Fewell, Rolf Renne, Erik K. Flemington;
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Sophie Maiga, Carole Brosseau, Geraldine Descamps, Christelle Dousset, Patricia Gomez-Bougie, David Chiron, Emmanuelle Menoret, Charlotte Kervoelen, Henri Vie, Anne Cesbron, Agnes Moreau-Aubry ...Show all 13 authors... , Martine Amiot, Catherine Pellat-Deceunynck; Show fewer authors
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, De-Kuang Zhao, Xiao-Yu Jiang, Elif Isik, Anthony George Letai, Izidore S. Lossos;
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) AddexBio; C0003033/4947
ATCC; CRL-3000
DSMZ; ACC-687
Cell line databases/resources cancercelllines; CVCL_1872
Cell_Model_Passport; SIDM01667
DepMap; ACH-000220
DSMZCellDive; ACC-687
Lonza; 165
Biological sample resources BioSample; SAMN03471705
BioSample; SAMN10988480
Chemistry resources ChEMBL-Cells; CHEMBL4523520
ChEMBL-Targets; CHEMBL4523551
PharmacoDB; Mino_932_2019
PubChem_Cell_line; CVCL_1872
Encyclopedic resources Wikidata; Q54905748
Experimental variables resources EFO; EFO_0022501
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM629496
GEO; GSM629497
GEO; GSM887321
GEO; GSM888397
GEO; GSM907522
GEO; GSM1044970
GEO; GSM1044971
GEO; GSM1044972
GEO; GSM1044973
GEO; GSM1670110
GEO; GSM2322625
Polymorphism and mutation databases Cosmic; 2078181
Cosmic; 2088019
Cosmic; 2756236
IARC_TP53; 17152
LiGeA; CCLE_916
Progenetix; CVCL_1872
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37