ID   Mino
AC   CVCL_1872
SY   MINO
DR   EFO; EFO_0022501
DR   AddexBio; C0003033/4947
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   ATCC; CRL-3000
DR   BioSample; SAMN03471705
DR   BioSample; SAMN10988480
DR   cancercelllines; CVCL_1872
DR   Cell_Model_Passport; SIDM01667
DR   ChEMBL-Cells; CHEMBL4523520
DR   ChEMBL-Targets; CHEMBL4523551
DR   Cosmic; 2078181
DR   Cosmic; 2088019
DR   Cosmic; 2756236
DR   DepMap; ACH-000220
DR   DSMZ; ACC-687
DR   DSMZCellDive; ACC-687
DR   GEO; GSM629496
DR   GEO; GSM629497
DR   GEO; GSM887321
DR   GEO; GSM888397
DR   GEO; GSM907522
DR   GEO; GSM1044970
DR   GEO; GSM1044971
DR   GEO; GSM1044972
DR   GEO; GSM1044973
DR   GEO; GSM1670110
DR   GEO; GSM2322625
DR   IARC_TP53; 17152
DR   LiGeA; CCLE_916
DR   Lonza; 165
DR   PharmacoDB; Mino_932_2019
DR   Progenetix; CVCL_1872
DR   PubChem_Cell_line; CVCL_1872
DR   Wikidata; Q54905748
RX   PubMed=12127561;
RX   PubMed=12683869;
RX   PubMed=21746927;
RX   PubMed=22460905;
RX   PubMed=24362935;
RX   PubMed=25315077;
RX   PubMed=25355872;
RX   PubMed=25688540;
RX   PubMed=25960936;
RX   PubMed=26194763;
RX   PubMed=28196595;
RX   PubMed=29666304;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: LL-100 blood cancer cell line panel.
CC   Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Doubling time: 72 hours (PubMed=25315077); ~50 hours (DSMZ=ACC-687).
CC   HLA typing: A*11:01,68:01; B*35:01,39:01; C*04:01,12:03; DQA1*01:02,01:02; DQB1*05:01,06:03; DRB1*01:01,13:01 (PubMed=25960936).
CC   HLA typing: A*11,68; B*35,39; C*04,12 (PubMed=25688540).
CC   HLA typing: A*11:01:01,68:01:01; B*35:01:01,39:01:01; C*04:01:01,12:03:01; DPA1*01:03:01,02:01:01; DPB1*10:01:01,10:01:01; DQA1*01:03:01,01:01:01; DQB1*05:01:01,06:03:01; DRA*01:01:01,01:02:02; DRB1*01:01:01,13:01:01 (DSMZCellDive=ACC-687).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu88Lys (c.262G>A); ClinVar=VCV000821566; Zygosity=Homozygous (DepMap=ACH-000220).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000013901; Zygosity=Heterozygous (DepMap=ACH-000220).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val147Gly (c.440T>G); Zygosity=Homozygous (DepMap=ACH-000220).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq virome analysis.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.85%; Native American=0%; East Asian, North=1.5%; East Asian, South=0%; South Asian=6.1%; European, North=39.56%; European, South=51.98% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): AddexBio=C0003033/4947; ATCC=CRL-3000; DSMZ=ACC-687
ST   Amelogenin: X,Y
ST   CSF1PO: 9,11
ST   D13S317: 12
ST   D16S539: 11,12
ST   D18S51: 12,14
ST   D19S433: 15
ST   D21S11: 29,30
ST   D2S1338: 23
ST   D3S1358: 18
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   D8S1179: 13
ST   FGA: 23,25
ST   Penta D: 12,13
ST   Penta E: 5,17
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 14,17
DI   NCIt; C4337; Mantle cell lymphoma
DI   ORDO; Orphanet_52416; Mantle cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 37
//
RX   PubMed=12127561; DOI=10.1016/S0145-2126(02)00013-9;
RA   Lai, Raymond
RA   McDonnell, Timothy J.
RA   O'Connor, Sean L.
RA   Medeiros, L. Jeffrey
RA   Oudat, Raida I.
RA   Keating, Michael J.
RA   Morgan, Myra B.
RA   Curiel, Tyler Jay
RA   Ford, Richard Joseph Jr.
RT   "Establishment and characterization of a new mantle cell lymphoma cell
RT   line, Mino.";
RL   Leuk. Res. 26:849-855(2002).
//
RX   PubMed=25315077; DOI=10.3109/10428194.2014.970548;
RA   Fogli, Laura K.
RA   Williams, Michael E.
RA   Connors, Joseph M.
RA   Reid, Yvonne A.
RA   Brown, Kathleen
RA   O'Connor, Owen A.
RT   "Development and characterization of a Mantle Cell Lymphoma Cell Bank
RT   in the American Type Culture Collection.";
RL   Leuk. Lymphoma 56:2114-2122(2015).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332;
RA   Bhatt, Shruti
RA   Matthews, Julie
RA   Parvin, Salma
RA   Sarosiek, Kristopher A.
RA   Zhao, De-Kuang
RA   Jiang, Xiao-Yu
RA   Isik, Elif
RA   Letai, Anthony George
RA   Lossos, Izidore S.
RT   "Direct and immune-mediated cytotoxicity of interleukin-21 contributes
RT   to antitumor effects in mantle cell lymphoma.";
RL   Blood 126:1555-1564(2015).
//
RX   PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004;
RA   Pham, Lan V.
RA   Huang, Sheng-Jian
RA   Zhang, Hui
RA   Zhang, Jun
RA   Bell, Taylor
RA   Zhou, Shou-Hao
RA   Pogue, Elizabeth
RA   Ding, Zhi-Yong
RA   Lam, Laura
RA   Westin, Jason
RA   Davis, R. Eric
RA   Young, Ken H.
RA   Medeiros, L. Jeffrey
RA   Ford, Richard Joseph Jr.
RA   Nomie, Krystle
RA   Zhang, Leo
RA   Wang, Michael
RT   "Strategic therapeutic targeting to overcome venetoclax resistance in
RT   aggressive B-cell lymphomas.";
RL   Clin. Cancer Res. 24:3967-3980(2018).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=25688540; DOI=10.1002/cyto.a.22643;
RA   Maiga, Sophie
RA   Brosseau, Carole
RA   Descamps, Geraldine
RA   Dousset, Christelle
RA   Gomez-Bougie, Patricia
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Kervoelen, Charlotte
RA   Vie, Henri
RA   Cesbron, Anne
RA   Moreau-Aubry, Agnes
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A simple flow cytometry-based barcode for routine authentication of
RT   multiple myeloma and mantle cell lymphoma cell lines.";
RL   Cytometry A 87:285-288(2015).
//
RX   PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145;
RA   Cao, Su-Bing
RA   Strong, Michael J.
RA   Wang, Xia
RA   Moss, Walter N.
RA   Concha, Monica
RA   Lin, Zhen
RA   O'Grady, Tina
RA   Baddoo, Melody
RA   Fewell, Claire
RA   Renne, Rolf
RA   Flemington, Erik K.
RT   "High-throughput RNA sequencing-based virome analysis of 50 lymphoma
RT   cell lines from the Cancer Cell Line Encyclopedia project.";
RL   J. Virol. 89:713-729(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=12683869; DOI=10.5858/2003-127-0424-COMCLC;
RA   Amin, Hesham M.
RA   McDonnell, Timothy J.
RA   Medeiros, L. Jeffrey
RA   Rassidakis, Georgios Z.
RA   Leventaki, Vasiliki
RA   O'Connor, Sean L.
RA   Keating, Michael J.
RA   Lai, Raymond
RT   "Characterization of 4 mantle cell lymphoma cell lines. Establishment
RT   of an in vitro study model.";
RL   Arch. Pathol. Lab. Med. 127:424-431(2003).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=24362935; DOI=10.1038/nm.3435;
RA   Rahal, Rami
RA   Frick, Mareike
RA   Romero, Rodrigo
RA   Korn, Joshua M.
RA   Kridel, Robert
RA   Chan, Fong Chun
RA   Meissner, Barbara
RA   Bhang, Hyo-eun Carrie
RA   Ruddy, David A.
RA   Kauffmann, Audrey
RA   Farsidjani, Ali
RA   Derti, Adnan
RA   Rakiec, Daniel
RA   Naylor, Tara
RA   Pfister, Estelle
RA   Kovats, Steve
RA   Kim, Sunkyu
RA   Dietze, Kerstin
RA   Dorken, Bernd
RA   Steidl, Christian
RA   Tzankov, Alexandar
RA   Hummel, Michael
RA   Monahan, John E.
RA   Morrissey, Michael P.
RA   Fritsch, Christine
RA   Sellers, William Raj
RA   Cooke, Vesselina G.
RA   Gascoyne, Randy D.
RA   Lenz, Georg
RA   Stegmeier, Frank
RT   "Pharmacological and genomic profiling identifies NF-kappaB-targeted
RT   treatment strategies for mantle cell lymphoma.";
RL   Nat. Med. 20:87-92(2014).
//
RX   PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731;
RA   Beltran, Elena
RA   Fresquet, Vicente
RA   Martinez-Useros, Javier
RA   Richter-Larrea, Jose A.
RA   Sagardoy, Ainara
RA   Sesma, Izaskun
RA   Almada, Luciana L.
RA   Montes-Moreno, Santiago
RA   Siebert, Reiner
RA   Gesk, Stefan
RA   Calasanz, Maria J.
RA   Malumbres, Raquel
RA   Rieger, Melissa
RA   Prosper, Felipe
RA   Lossos, Izidore S.
RA   Piris, Miguel Angel
RA   Fernandez-Zapico, Martin E.
RA   Martinez-Climent, Jose Angel
RT   "A cyclin-D1 interaction with BAX underlies its oncogenic role and
RT   potential as a therapeutic target in mantle cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).
//