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Cellosaurus CCRF-SB (CVCL_1860)

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Cell line name CCRF-SB
Synonyms CCRF SB; CCRFSB; SB; S.B.; GM04154; GM04154B
Accession CVCL_1860
Resource Identification Initiative To cite this cell line use: CCRF-SB (RRID:CVCL_1860)
Comments Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*44:05,57:01
HLA-CC*02:02,06:02
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1859 ! CCRF-HSB-2
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-120; JCRB=IFO50026; JCRB=JCRB0032; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817,18
D3S135816,17
D5S81811,12
D7S82011,12
D8S11799,15
D13S31710,12
D16S5399,13 (ATCC=CCL-120; PubMed=25877200)
13 (JCRB=IFO50026; JCRB=JCRB0032)
D18S519,14
D19S43314,16
D21S1127,28
FGA25
Penta D9,12
Penta E6,13
TH019,10
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=4991454; DOI=10.1016/0014-4827(79)90504-4
Richard A. Adams, Lillian Pothier, Arlene Flowers, Herbert Lazarus, Sidney Farber, George E. Foley;
The question of stemlines in human acute leukemia. Comparison of cells isolated in vitro and in vivo from a patient with acute lymphoblastic leukemia.
Exp. Cell Res. 62:5-10(1970)

PubMed=4363409; DOI=10.1084/jem.139.5.1070; PMCID=PMC2139653
Joseph Kaplan, Thomas C. Shope, Ward Davis Peterson Jr.;
Epstein-Barr virus-negative human malignant T-cell lines.
J. Exp. Med. 139:1070-1076(1974)

PubMed=4523807; DOI=10.1007/BF02616012
Herbert Lazarus, Elizabeth Ferguson Barell, Selma O. Oppenheim, Awtar Krishan;
Divergent properties of two human lymphocytic cell lines isolated from a single specimen of peripheral blood.
In Vitro 9:303-310(1974)

PubMed=62390; DOI=10.1111/j.1365-3083.1976.tb03029.x
William J. Yount, Peter D. Utsinger, Lindsey M. Hutt, Philip D. Buchanan, Joseph H. Korn, C. Randall Fuller, Marshall J. Logue, Joseph S. Pagano;
Subpopulations of human lymphoblastoid cell lines. Correlation with the expression of surface receptors and content of Epstein-Barr virus genome.
Scand. J. Immunol. 5:795-810(1976)

PubMed=1086134
Joseph Kaplan, Ward Davis Peterson Jr.;
Detection of T-cell lymphoma-associated antigens on cord blood lymphocytes and phytohemagglutinin-stimulated blasts.
Cancer Res. 36:3471-3475(1976)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=8316623; DOI=10.2307/3578190
Helen Harrington Evans, Marlene Ricanati, Min-Fen Horng, Qiao-Yun Jiang, Jaroslav Mencl, Peggy Louise Olive;
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
Radiat. Res. 134:307-315(1993)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783
Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano ...Show all 15 authors... , Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara; Show fewer authors
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) ATCC; CCL-120
CCTCC; GDC0304
Coriell; GM04154
ECACC; 89090405
IZSLER; BS TCL 12
JCRB; IFO50026
JCRB; JCRB0032
NCI-DTP; CCRF-SB
Cell line databases/resources CLO; CLO_0002336
CLO; CLO_0016198
CLDB; cl679
CLDB; cl680
CLDB; cl681
cancercelllines; CVCL_1860
CCRID; 4201HUM-CCTCC00304
IGRhCellID; CCRFSB
LINCS_LDP; LCL-1006
Biological sample resources BioSample; SAMN03471043
BioSample; SAMN03472769
Chemistry resources ChEMBL-Cells; CHEMBL3307643
ChEMBL-Targets; CHEMBL614542
PharmacoDB; CCRFSB_191_2019
PubChem_Cell_line; CVCL_1860
Encyclopedic resources Wikidata; Q54809040
Experimental variables resources EFO; EFO_0006550
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM5137709
Polymorphism and mutation databases Cosmic; 683533
Cosmic; 2301562
Cosmic; 2649231
IARC_TP53; 21219
Progenetix; CVCL_1860
Proteomic databases PRIDE; PXD023662
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34