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Cellosaurus Namalwa.IPN/45 (CVCL_1839)

[Text version]

Cell line name Namalwa.IPN/45
Synonyms NAMALWA.IPN/45; NAMALWA-IPN.45; Namalwa IPN/45; IPN/45
Accession CVCL_1839
Resource Identification Initiative To cite this cell line use: Namalwa.IPN/45 (RRID:CVCL_1839)
Comments Population: African; Kenyan.
Characteristics: Contains 2 integrated copies of EBV genome on chromosome 1.
Characteristics: Infected by squirrel monkey retrovirus (SMRV) (PubMed=1339415; PubMed=20454443). Contains two partial SMRV copies integrated into the MYC gene locus and 10 further copies integrated at different sites of the genome.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0067 (Namalwa)
Sex of cell Female
Age at sampling Children
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,21
D3S135816
D5S81812,13
D7S82011
D8S117913,15
D13S31711,12
D16S5399
D18S5115
D19S43314,18
D21S1127,28
FGA22
Penta D8,13
Penta E5,15
TH017,9.3
TPOX6,11
vWA14,16

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=IPN%2f45
Publications

PubMed=3026962
Guy K., Middleton P.G., Docherty L.J., De Angelis C.L., Steel C.M.
MHC class II antigen and immunoglobulin expression in spontaneous phenotypic variants of the Burkitt's lymphoma cell line Namalwa.
Immunology 59:603-610(1986)

PubMed=2298494; DOI=10.1002/ijc.2910450120
Guy K., Middleton P.G., Bansal N.S., Ross J.A., Steel C.M.
Recurrent mutation of immunoglobulin and c-myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a Burkitt lymphoma.
Int. J. Cancer 45:109-118(1990)

PubMed=1339415; DOI=10.1002/ijc.2910520320
Middleton P.G., Miller S., Ross J.A., Steel C.M., Guy K.
Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell line and presence in established cell lines.
Int. J. Cancer 52:451-454(1992)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

Cross-references
Cell line collections DSMZ; ACC-71
Cell line databases/resources CLO; CLO_0007941
CLDB; cl3639
DSMZCellDive; ACC-71
Biological sample resources BioSample; SAMN03473394
Encyclopedic resources Wikidata; Q54907453
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number20