ID   Namalwa.IPN/45
AC   CVCL_1839
SY   NAMALWA.IPN/45; NAMALWA-IPN.45; Namalwa IPN/45; IPN/45
DR   CLO; CLO_0007941
DR   CLDB; cl3639
DR   BioSample; SAMN03473394
DR   cancercelllines; CVCL_1839
DR   DSMZ; ACC-71
DR   DSMZCellDive; ACC-71
DR   Wikidata; Q54907453
RX   PubMed=1339415;
RX   PubMed=2298494;
RX   PubMed=3026962;
RX   PubMed=7849311;
RX   PubMed=20454443;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=IPN%2f45
CC   Population: African; Kenyan.
CC   Virology: Contains 2 integrated copies of EBV genome on chromosome 1.
CC   Virology: Infected by squirrel monkey retrovirus (SMRV) (PubMed=1339415; PubMed=20454443). Contains two partial SMRV copies integrated into the MYC gene locus and 10 further copies integrated at different sites of the genome.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): DSMZ=ACC-71
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 15
ST   D19S433: 14,18
ST   D21S11: 27,28
ST   D2S1338: 17,21
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 11
ST   D8S1179: 13,15
ST   FGA: 22
ST   Penta D: 8,13
ST   Penta E: 5,15
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 14,16
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0067 ! Namalwa
SX   Female
AG   Children
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=1339415; DOI=10.1002/ijc.2910520320;
RA   Middleton, Peter Gelder
RA   Miller, S.
RA   Ross, James A.
RA   Steel, Christopher Michael
RA   Guy, Keith
RT   "Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell
RT   line and presence in established cell lines.";
RL   Int. J. Cancer 52:451-454(1992).
//
RX   PubMed=2298494; DOI=10.1002/ijc.2910450120;
RA   Guy, Keith
RA   Middleton, Peter Gelder
RA   Bansal, Narinder S.
RA   Ross, James A.
RA   Steel, Christopher Michael
RT   "Recurrent mutation of immunoglobulin and c-myc genes and differential
RT   expression of cell surface antigens occur in variant cell lines
RT   derived from a Burkitt lymphoma.";
RL   Int. J. Cancer 45:109-118(1990).
//
RX   PubMed=3026962; PMCID=PMC1453332;
RA   Guy, Keith
RA   Middleton, Peter Gelder
RA   Docherty, Linda J.M.
RA   De Angelis, C.L.
RA   Steel, Christopher Michael
RT   "MHC class II antigen and immunoglobulin expression in spontaneous
RT   phenotypic variants of the Burkitt's lymphoma cell line Namalwa.";
RL   Immunology 59:603-610(1986).
//
RX   PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893;
RA   Stranks, Gail
RA   Height, Susan E.
RA   Mitchell, Paul
RA   Jadayel, Dalal Mouneimne
RA   Yuille, Martin A.R.
RA   De Lord, Corinne F.M.
RA   Clutterbuck, Robyn D.
RA   Treleaven, Jennie G.
RA   Powles, Ray Leonard
RA   Nacheva, Elisabeth
RA   Oscier, David G.
RA   Karpas, Abraham
RA   Lenoir, Gilbert Marcel
RA   Smith, Stephen D.
RA   Millar, John L.
RA   Catovsky, Daniel
RA   Dyer, Martin John Swinnerton
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
//