ID   Namalwa.IPN/45
AC   CVCL_1839
SY   NAMALWA.IPN/45; NAMALWA-IPN.45; Namalwa IPN/45; IPN/45
DR   CLO; CLO_0007941
DR   CLDB; cl3639
DR   BioSample; SAMN03473394
DR   cancercelllines; CVCL_1839
DR   DSMZ; ACC-71
DR   DSMZCellDive; ACC-71
DR   Wikidata; Q54907453
RX   PubMed=1339415;
RX   PubMed=2298494;
RX   PubMed=3026962;
RX   PubMed=7849311;
RX   PubMed=20454443;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=IPN%2f45
CC   Population: African; Kenyan.
CC   Virology: Contains 2 integrated copies of EBV genome on chromosome 1.
CC   Virology: Infected by squirrel monkey retrovirus (SMRV) (PubMed=1339415; PubMed=20454443). Contains two partial SMRV copies integrated into the MYC gene locus and 10 further copies integrated at different sites of the genome.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
ST   Source(s): DSMZ
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 15
ST   D19S433: 14,18
ST   D21S11: 27,28
ST   D2S1338: 17,21
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 11
ST   D8S1179: 13,15
ST   FGA: 22
ST   Penta D: 8,13
ST   Penta E: 5,15
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 14,16
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0067 ! Namalwa
SX   Female
AG   Children
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
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RX   PubMed=1339415; DOI=10.1002/ijc.2910520320;
RA   Middleton P.G., Miller S., Ross J.A., Steel C.M., Guy K.;
RT   "Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell
RT   line and presence in established cell lines.";
RL   Int. J. Cancer 52:451-454(1992).
//
RX   PubMed=2298494; DOI=10.1002/ijc.2910450120;
RA   Guy K., Middleton P.G., Bansal N.S., Ross J.A., Steel C.M.;
RT   "Recurrent mutation of immunoglobulin and c-myc genes and differential
RT   expression of cell surface antigens occur in variant cell lines
RT   derived from a Burkitt lymphoma.";
RL   Int. J. Cancer 45:109-118(1990).
//
RX   PubMed=3026962;
RA   Guy K., Middleton P.G., Docherty L.J., De Angelis C.L., Steel C.M.;
RT   "MHC class II antigen and immunoglobulin expression in spontaneous
RT   phenotypic variants of the Burkitt's lymphoma cell line Namalwa.";
RL   Immunology 59:603-610(1986).
//
RX   PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893;
RA   Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R.,
RA   De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L.,
RA   Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D.,
RA   Millar J.L., Catovsky D., Dyer M.J.S.;
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767;
RA   Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.;
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//