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Cellosaurus LAZ-221 (CVCL_1830)

[Text version]
Cell line name LAZ-221
Synonyms Laz-221; LAZ 221; Laz 221; LAZ221; Laz221
Accession CVCL_1830
Resource Identification Initiative To cite this cell line use: LAZ-221 (RRID:CVCL_1830)
Comments From: Lazarus, Herbert; Dana-Farber Cancer Institute; Boston; USA.
Population: Caucasian.
Doubling time: ~4 days (PubMed=205365); ~50-80 hours (DSMZ=ACC-716).
Karyotypic information: 45,XX,-9,-12,+t(9q;12q) (PubMed=205365).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: PubMed=2939141
Class I
HLA-AA*01,24
HLA-BB*22,35
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_GY04 ! LAZ-388
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-716

Markers:
AmelogeninX
CSF1PO11,12
D2S133818
D3S135816,17
D5S81811,14
D7S8208,11
D8S117911,13
D13S31711,13
D16S53911
D18S5117,22
D19S43312,15
D21S1130,31
FGA20,21
Penta D11,13
Penta E10,11
TH018,9
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=205365
Lazarus H., Barell E.F., Krishan A., Livingston D.M., Harris K., Schlossman S.F., Chess L.
Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ('null' cell) leukemia.
Cancer Res. 38:1362-1367(1978)

PubMed=7108207; DOI=10.4049/jimmunol.129.3.1299
Hercend T., Meuer S.C., Reinherz E.L., Schlossman S.F., Ritz J.
Generation of a cloned NK cell line derived from the 'null cell' fraction of human peripheral blood.
J. Immunol. 129:1299-1305(1982)

Patent=US4550086
Reinherz E.L., Schlossman S.F., Meuer S.C.
Monoclonal antibodies that recognize human T cells.
Patent number US4550086, 29-Oct-1985

PubMed=2939141; DOI=10.4049/jimmunol.136.11.4311
Pesando J.M., Graf L.
Differential expression of HLA-DR, -DQ, and -DP antigens on malignant B cells.
J. Immunol. 136:4311-4318(1986)

PubMed=8315353; DOI=10.1002/jlb.53.6.697
Woolfrey A.E., Andersen L.C., Shewey L., Chung J., Nepom G.T.
Analysis of differential HLA-DQB expression in autologous B cell lines.
J. Leukoc. Biol. 53:697-706(1993)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=21326318; DOI=10.1038/gene.2010.77; PMCID=PMC3107363
Majumder P., Boss J.M.
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture.
Genes Immun. 12:291-299(2011)

Cross-references
Cell line collections (Providers) DSMZ; ACC-716
Cell line databases/resources DSMZCellDive; ACC-716
Lonza; 126
Encyclopedic resources Wikidata; Q54901987
Polymorphism and mutation databases Cosmic; 798667
Cosmic; 801716
Cosmic; 994181
Cosmic; 998709
Cosmic; 1037710
Cosmic; 2491081
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number21