ID   LAZ-221
AC   CVCL_1830
SY   Laz-221; LAZ 221; Laz 221; LAZ221; Laz221
DR   Cosmic; 798667
DR   Cosmic; 801716
DR   Cosmic; 994181
DR   Cosmic; 998709
DR   Cosmic; 1037710
DR   Cosmic; 2491081
DR   DSMZ; ACC-716
DR   DSMZCellDive; ACC-716
DR   Lonza; 126
DR   Wikidata; Q54901987
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   Patent=US4550086;
RX   PubMed=205365;
RX   PubMed=2939141;
RX   PubMed=7108207;
RX   PubMed=8315353;
RX   PubMed=9067587;
RX   PubMed=9680106;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=21326318;
CC   From: Lazarus, Herbert; Dana-Farber Cancer Institute; Boston; USA.
CC   Population: Caucasian.
CC   Doubling time: ~4 days (PubMed=205365); ~50-80 hours (DSMZ=ACC-716).
CC   HLA typing: A*01,24; B*22,35 (PubMed=2939141).
CC   Karyotypic information: 45,XX,-9,-12,+t(9q;12q) (PubMed=205365).
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-716
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,13
ST   D16S539: 11
ST   D18S51: 17,22
ST   D19S433: 12,15
ST   D21S11: 30,31
ST   D2S1338: 18
ST   D3S1358: 16,17
ST   D5S818: 11,14
ST   D7S820: 8,11
ST   D8S1179: 11,13
ST   FGA: 20,21
ST   Penta D: 11,13
ST   Penta E: 10,11
ST   TH01: 8,9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_GY04 ! LAZ-388
SX   Female
AG   24Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 21
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   Patent=US4550086;
RA   Reinherz E.L., Schlossman S.F., Meuer S.C.;
RT   "Monoclonal antibodies that recognize human T cells.";
RL   Patent number US4550086, 29-Oct-1985.
//
RX   PubMed=205365;
RA   Lazarus H., Barell E.F., Krishan A., Livingston D.M., Harris K.,
RA   Schlossman S.F., Chess L.;
RT   "Characterization of a unique cell line (LAZ 221) from human acute
RT   lymphocytic ('null' cell) leukemia.";
RL   Cancer Res. 38:1362-1367(1978).
//
RX   PubMed=2939141; DOI=10.4049/jimmunol.136.11.4311;
RA   Pesando J.M., Graf L.;
RT   "Differential expression of HLA-DR, -DQ, and -DP antigens on malignant
RT   B cells.";
RL   J. Immunol. 136:4311-4318(1986).
//
RX   PubMed=7108207; DOI=10.4049/jimmunol.129.3.1299;
RA   Hercend T., Meuer S.C., Reinherz E.L., Schlossman S.F., Ritz J.;
RT   "Generation of a cloned NK cell line derived from the 'null cell'
RT   fraction of human peripheral blood.";
RL   J. Immunol. 129:1299-1305(1982).
//
RX   PubMed=8315353; DOI=10.1002/jlb.53.6.697;
RA   Woolfrey A.E., Andersen L.C., Shewey L., Chung J., Nepom G.T.;
RT   "Analysis of differential HLA-DQB expression in autologous B cell
RT   lines.";
RL   J. Leukoc. Biol. 53:697-706(1993).
//
RX   PubMed=9067587; DOI=10.1038/sj.leu.2400571;
RA   Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A.,
RA   Janssen J.W.G., Drexler H.G.;
RT   "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in
RT   human early B-lineage leukemia cell lines.";
RL   Leukemia 11:441-447(1997).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo Y., Drexler H.G.;
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000), 255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=21326318; DOI=10.1038/gene.2010.77; PMCID=PMC3107363;
RA   Majumder P., Boss J.M.;
RT   "DNA methylation dysregulates and silences the HLA-DQ locus by
RT   altering chromatin architecture.";
RL   Genes Immun. 12:291-299(2011).
//