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Cellosaurus VA-ES-BJ (CVCL_1785)

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Cell line name VA-ES-BJ
Synonyms VAESBJ; Valhalla-Epithelioid Sarcoma-BJ
Accession CVCL_1785
Resource Identification Initiative To cite this cell line use: VA-ES-BJ (RRID:CVCL_1785)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 36-39 hours (PubMed=21552805); ~32 hours (PubMed=21357725); ~60-90 hours (DSMZ=ACC-328).
Karyotypic information: Near triploid karyotype. Trisomy of chromosomes 2, 5, 8, 10, 12, 13, 16, 17, 18 and 19, tetrasomy of chromosomes 6, 20 and 21 and pentasomy of chromosome 7 (PubMed=21552805).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7773; NF2; Simple; p.Ser87Ter (c.260C>A); Zygosity=Homozygous (Cosmic-CLP=688121; DepMap=ACH-001702).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.49
Native American0
East Asian, North0
East Asian, South0
South Asian3.35
European, North67.75
European, South28.41
Disease Epithelioid sarcoma (NCIt: C3714)
Epithelioid sarcoma (ORDO: Orphanet_293202)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QW58 (VA-ES-BJ BAF47)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2138; Cosmic-CLP=688121; DepMap=ACH-001702; DSMZ=ACC-328; ECACC=94092303; ICLC=HTL97024

Markers:
AmelogeninX
CSF1PO11,12
D2S133816,17
D3S135816
D5S81811,13
D7S82011,12
D8S117911 (DSMZ=ACC-328)
11,15 (ATCC=CRL-2138; DepMap=ACH-001702)
D13S31711,12
D16S53911,12
D18S5112,13
D19S43314
D21S1127,28
FGA22
Penta D7,10,13 (DepMap=ACH-001702)
10,13 (ATCC=CRL-2138; DSMZ=ACC-328)
Penta E13
TH016
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=21552805; DOI=10.3892/ijo.7.1.51
Christiane Helson, Myron Roy Melamed, Susan Braverman, Frank Traganos, Robert A. Preti, Lawrence Helson;
VA-ES-BJ -- an epithelioid sarcoma cell-line.
Int. J. Oncol. 7:51-56(1995)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21357725; DOI=10.1634/theoncologist.2010-0174; PMCID=PMC3228127
Aniket Sakharpe, Guy Lahat, Taher Gulamhusein, Ping Liu, Svetlana V. Bolshakov, Theresa Nguyen, Ping-Yu Zhang, Roman Belousov, Eric D. Young, Xian-Biao Xie, Priya Rao ...Show all 15 authors... , Jason L. Hornick, Alexander J.F. Lazar, Raphael E. Pollock, Dina Chelouche Lev; Show fewer authors
Epithelioid sarcoma and unclassified sarcoma with epithelioid features: clinicopathological variables, molecular markers, and a new experimental model.
Oncologist 16:512-522(2011)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26365879; DOI=10.1002/path.4636
Farzad Jamshidi, Ali Bashashati, Karey Shumansky, Brendan Dickson, Nalan Gokgoz, Jay Steven Wunder, Irene L. Andrulis, Alexander J.F. Lazar, Sohrab P. Shah, David G. Huntsman, Torsten O. Nielsen;
The genomic landscape of epithelioid sarcoma cell lines and tumours.
J. Pathol. 238:63-73(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28945250; DOI=10.1038/ng.3958; PMCID=PMC5803080
Robert T. Nakayama, John L. Pulice, Alfredo M. Valencia, Matthew J. McBride, Zachary M. McKenzie, Mark A. Gillespie, Wai Lim Ku, Ming-Xiang Teng, Kai-Rong Cui, Robert T. Williams, Seth H. Cassel ...Show all 18 authors... , He Qing, Christian J. Widmer, George Daniel Demetri, Rafael Angel Irizarry, Ke-Ji Zhao, Jeffrey A. Ranish, Cigall Kadoch; Show fewer authors
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.
Nat. Genet. 49:1613-1623(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2138
DSMZ; ACC-328
ECACC; 94092303
ICLC; HTL97024
Cell line databases/resources CLO; CLO_0009509
CLDB; cl4635
CLDB; cl4636
Cell_Model_Passport; SIDM01179
Cosmic-CLP; 688121
DepMap; ACH-001702
DSMZCellDive; ACC-328
LINCS_LDP; LCL-1945
Biological sample resources BioSample; SAMN03472555
Chemistry resources ChEMBL-Cells; CHEMBL3308888
ChEMBL-Targets; CHEMBL2366259
GDSC; 688121
PharmacoDB; VAESBJ_1651_2019
PubChem_Cell_line; CVCL_1785
Encyclopedic resources Wikidata; Q54992642
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1632462
GEO; GSM1632463
GEO; GSM1632464
GEO; GSM1632465
GEO; GSM1670569
GEO; GSM1676344
GEO; GSM1701675
GEO; GSM2409694
GEO; GSM2409695
GEO; GSM2409696
GEO; GSM2409697
GEO; GSM2409698
GEO; GSM2409699
GEO; GSM2787358
Polymorphism and mutation databases Cosmic; 688121
IARC_TP53; 21268
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38