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Cellosaurus TT (CVCL_1774)

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Cell line name TT
Synonyms MTC-TT
Accession CVCL_1774
Resource Identification Initiative To cite this cell line use: TT (RRID:CVCL_1774)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~83 hours (ATCC=CRL-1803).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Cell type: Parafollicular cell; CL=CL_0000570.
Sequence variations
  • Mutation; HGNC; HGNC:9967; RET; Simple; p.Cys634Trp (c.1902C>G); ClinVar=VCV000013918; Zygosity=Heterozygous (PubMed=7736432; PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
  • Mutation; HGNC; HGNC:11602; TBX3; Simple; p.Trp197Ter (c.591G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*51:01,67:02
HLA-CC*12:03,14:02
Class II
HLA-DQDQB1*05:01,06:07
HLA-DRDRB1*01:01,11:10
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.11
Native American0
East Asian, North2.03
East Asian, South0
South Asian6.11
European, North32.67
European, South57.09
Disease Hereditary thyroid gland medullary carcinoma (NCIt: C46099)
Multiple endocrine neoplasia type 2 (NCIt: C123329)
Familial medullary thyroid carcinoma (ORDO: Orphanet_99361)
Multiple endocrine neoplasia type 2 (ORDO: Orphanet_653)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1803; CCRID; Cosmic-CLP=930299; ECACC=92050721; ICLC=HTL98004; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,23
D3S135815
D5S81812,13
D7S82010,12
D8S117915,16
D13S31711
D16S53912,13
D18S5112
D19S43314,15
D21S1129,32.2
FGA21,25
Penta D13
Penta E7,13
TH016,9
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/normal-growth-and-morphology-of-atcc-crl-1803-the-tt-cells
Publications

CLPUB00116
Susan S. Leong, Julius Stanislaw Horoszewicz, Keiji Shimaoka, M. Friedmann, Elzbieta Kawinski, Min Jong Song, Robert Francis Zeigel, Tsann Ming Chu, Stephen Bruce Baylin, Edwin A. Mirand;
A new cell line for study of human medullary thyroid carcinoma.
(In book chapter) Advances in thyroid neoplasia; Andreoli, Mario & Monaco, Fabrizio & Robbins, Jacob (eds.); pp.95-108; Field Educational Italia; Roma; Italy (1981)

PubMed=3467830; DOI=10.1016/0165-4608(87)90156-7
Kimio Tanaka, Stephen Bruce Baylin, Barry D. Nelkin, Joseph R. Testa;
Cytogenetic studies of a human medullary thyroid carcinoma cell line.
Cancer Genet. Cytogenet. 25:27-35(1987)

PubMed=2519210
Toru Kameya, Kuniko Kadoya, Haruo Iguchi;
Characterization and calcitonin secretion of a human well differentiated C-cell tumor cell line.
Hum. Cell 2:231-237(1989)

PubMed=1516062
Katsuhiko Yoshimoto, Hiroyuki Iwahana, Ayumi Fukuda, Toshiaki Sano, Shiro Saito, Mitsuo Itakura;
Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Cancer Res. 52:5061-5064(1992)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E
Linda D. Cooley, Frederick F.B. Elder, Alexander Knuth, Robert F. Gagel;
Cytogenetic characterization of three human and three rat medullary thyroid carcinoma cell lines.
Cancer Genet. Cytogenet. 80:138-149(1995)

PubMed=7864888; DOI=10.1006/bbrc.1995.1287
Francesca Carlomagno, Domenico Salvatore, Massimo Mattia Santoro, Vittorio de Franciscis, Loredano Quadro, Luigi Panariello, Vittorio Colantuoni, Alfredo Fusco;
Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line.
Biochem. Biophys. Res. Commun. 207:1022-1028(1995)

PubMed=9046062; DOI=10.14670/HH-12.283
Maciej Zabel, Jan Grzeszkowiak;
Characterisation of thyroid medullary carcinoma TT cell line.
Histol. Histopathol. 12:283-289(1997)

PubMed=11751535; DOI=10.1093/clinchem/48.1.25
Nathalie Zammatteo, Laurence Lockman, Francis Brasseur, Etienne De Plaen, Christophe Lurquin, Pierre-Emmanuel Lobert, Sandrine Hamels, Thierry Boon, Jose Remacle;
DNA microarray to monitor the expression of MAGE-A genes.
Clin. Chem. 48:25-34(2002)

PubMed=19897677; DOI=10.1210/jc.2009-1485; PMCID=PMC2805480
Wen Zhu, Tao Hai, Lei Ye, Gilbert J. Cote;
Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on Ret proto-oncogene activity.
J. Clin. Endocrinol. Metab. 95:439-444(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1803
BCRC; 60346
BCRJ; 0259
CCTCC; GDC0073
CLS; 305027
ECACC; 92050721
ICLC; HTL98004
KCB; KCB 2013001YJ
Cell line databases/resources CLO; CLO_0009421
CLDB; cl4547
CLDB; cl4901
cancercelllines; CVCL_1774
CCRID; 1101HUM-PUMC000268
CCRID; 3101HUMTCHu78
CCRID; 4201HUM-CCTCC00073
Cell_Model_Passport; SIDM00484
Cosmic-CLP; 930299
DepMap; ACH-001321
IGRhCellID; TT
LINCS_LDP; LCL-1690
Lonza; 1097
Anatomy/cell type resources BTO; BTO_0003074
Biological sample resources BioSample; SAMN03471250
BioSample; SAMN10988442
Chemistry resources ChEMBL-Cells; CHEMBL3308145
ChEMBL-Targets; CHEMBL2366083
GDSC; 930299
PharmacoDB; TT_1606_2019
PubChem_Cell_line; CVCL_1774
Encyclopedic resources Wikidata; Q54973178
Experimental variables resources EFO; EFO_0002382
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887714
GEO; GSM888807
GEO; GSM1374966
GEO; GSM1670548
Polymorphism and mutation databases Cosmic; 796049
Cosmic; 796731
Cosmic; 930299
Cosmic; 1005455
Cosmic; 1094763
Cosmic; 1175889
Cosmic; 1239955
Cosmic; 1608835
Cosmic; 1612901
Cosmic; 1699419
Cosmic; 1876248
Cosmic; 2036697
Cosmic; 2050374
IARC_TP53; 27017
IARC_TP53; 30182
LiGeA; CCLE_452
Progenetix; CVCL_1774
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41