ID   TT
AC   CVCL_1774
SY   MTC-TT
DR   BTO; BTO:0003074
DR   CLO; CLO_0009421
DR   EFO; EFO_0002382
DR   CLDB; cl4547
DR   CLDB; cl4901
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1803
DR   BCRC; 60346
DR   BCRJ; 0259
DR   BioSample; SAMN03471250
DR   BioSample; SAMN10988442
DR   cancercelllines; CVCL_1774
DR   CCRID; 1101HUM-PUMC000268
DR   CCRID; 3101HUMTCHu78
DR   CCRID; 4201HUM-CCTCC00073
DR   CCTCC; GDC0073
DR   Cell_Model_Passport; SIDM00484
DR   ChEMBL-Cells; CHEMBL3308145
DR   ChEMBL-Targets; CHEMBL2366083
DR   CLS; 305027
DR   Cosmic; 796049
DR   Cosmic; 796731
DR   Cosmic; 930299
DR   Cosmic; 1005455
DR   Cosmic; 1094763
DR   Cosmic; 1175889
DR   Cosmic; 1239955
DR   Cosmic; 1608835
DR   Cosmic; 1612901
DR   Cosmic; 1699419
DR   Cosmic; 1876248
DR   Cosmic; 2036697
DR   Cosmic; 2050374
DR   Cosmic-CLP; 930299
DR   DepMap; ACH-001321
DR   ECACC; 92050721
DR   EGA; EGAS00001000978
DR   GDSC; 930299
DR   GEO; GSM887714
DR   GEO; GSM888807
DR   GEO; GSM1374966
DR   GEO; GSM1670548
DR   IARC_TP53; 27017
DR   IARC_TP53; 30182
DR   ICLC; HTL98004
DR   IGRhCellID; TT
DR   KCB; KCB 2013001YJ
DR   LiGeA; CCLE_452
DR   LINCS_LDP; LCL-1690
DR   Lonza; 1097
DR   PharmacoDB; TT_1606_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1774
DR   PubChem_Cell_line; CVCL_1774
DR   Wikidata; Q54973178
RX   CelloPub=CLPUB00116;
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1516062;
RX   PubMed=2519210;
RX   PubMed=3467830;
RX   PubMed=7736432;
RX   PubMed=7864888;
RX   PubMed=9046062;
RX   PubMed=11751535;
RX   PubMed=19897677;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=22538498;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30737244;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35839778;
WW   https://www.atcc.org/en/support/technical-support/faqs/normal-growth-and-morphology-of-atcc-crl-1803-the-tt-cells
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~83 hours (ATCC=CRL-1803).
CC   HLA typing: A*02:01,03:01; B*51:01,67:02; C*12:03,14:02; DQB1*05:01,06:07; DRB1*01:01,11:10 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 9967; RET; Simple; p.Cys634Trp (c.1902C>G); ClinVar=VCV000013918; Zygosity=Heterozygous (PubMed=7736432; PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
CC   Sequence variation: Mutation; HGNC; 11602; TBX3; Simple; p.Trp197Ter (c.591G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=2.11%; Native American=0%; East Asian, North=2.03%; East Asian, South=0%; South Asian=6.11%; European, North=32.67%; European, South=57.09% (PubMed=30894373).
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
CC   Cell type: Parafollicular cell; CL=CL_0000570.
ST   Source(s): ATCC=CRL-1803; CCRID; Cosmic-CLP=930299; ECACC=92050721; ICLC=HTL98004; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 12
ST   D19S433: 14,15
ST   D21S11: 29,32.2
ST   D2S1338: 17,23
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 10,12
ST   D8S1179: 15,16
ST   FGA: 21,25
ST   Penta D: 13
ST   Penta E: 7,13
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C46099; Hereditary thyroid gland medullary carcinoma
DI   NCIt; C123329; Multiple endocrine neoplasia type 2
DI   ORDO; Orphanet_99361; Familial medullary thyroid carcinoma
DI   ORDO; Orphanet_653; Multiple endocrine neoplasia type 2
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 39
//
RX   CelloPub=CLPUB00116;
RA   Leong S.S., Horoszewicz J.S., Shimaoka K., Friedmann M., Kawinski E.,
RA   Song M.J., Zeigel R.F., Chu T.M., Baylin S.B., Mirand E.A.;
RT   "A new cell line for study of human medullary thyroid carcinoma.";
RL   (In) Advances in thyroid neoplasia; Andreoli M., Monaco H., Robbins J. (eds.); pp.95-108; Field Educational Italia; Roma (1981).
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1516062;
RA   Yoshimoto K., Iwahana H., Fukuda A., Sano T., Saito S., Itakura M.;
RT   "Role of p53 mutations in endocrine tumorigenesis: mutation detection
RT   by polymerase chain reaction-single strand conformation
RT   polymorphism.";
RL   Cancer Res. 52:5061-5064(1992).
//
RX   PubMed=2519210;
RA   Kameya T., Kadoya K., Iguchi H.;
RT   "Characterization and calcitonin secretion of a human well
RT   differentiated C-cell tumor cell line.";
RL   Hum. Cell 2:231-237(1989).
//
RX   PubMed=3467830; DOI=10.1016/0165-4608(87)90156-7;
RA   Tanaka K., Baylin S.B., Nelkin B.D., Testa J.R.;
RT   "Cytogenetic studies of a human medullary thyroid carcinoma cell
RT   line.";
RL   Cancer Genet. Cytogenet. 25:27-35(1987).
//
RX   PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E;
RA   Cooley L.D., Elder F.F.B., Knuth A., Gagel R.F.;
RT   "Cytogenetic characterization of three human and three rat medullary
RT   thyroid carcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 80:138-149(1995).
//
RX   PubMed=7864888; DOI=10.1006/bbrc.1995.1287;
RA   Carlomagno F., Salvatore D., Santoro M., de Franciscis V., Quadro L.,
RA   Panariello L., Colantuoni V., Fusco A.;
RT   "Point mutation of the RET proto-oncogene in the TT human medullary
RT   thyroid carcinoma cell line.";
RL   Biochem. Biophys. Res. Commun. 207:1022-1028(1995).
//
RX   PubMed=9046062; DOI=10.14670/HH-12.283;
RA   Zabel M., Grzeszkowiak J.;
RT   "Characterisation of thyroid medullary carcinoma TT cell line.";
RL   Histol. Histopathol. 12:283-289(1997).
//
RX   PubMed=11751535; DOI=10.1093/clinchem/48.1.25;
RA   Zammatteo N., Lockman L., Brasseur F., De Plaen E., Lurquin C.,
RA   Lobert P.-E., Hamels S., Boon T., Remacle J.;
RT   "DNA microarray to monitor the expression of MAGE-A genes.";
RL   Clin. Chem. 48:25-34(2002).
//
RX   PubMed=19897677; DOI=10.1210/jc.2009-1485;
RA   Zhu W., Hai T., Ye L., Cote G.J.;
RT   "Medullary thyroid carcinoma cell lines contain a self-renewing CD133+
RT   population that is dependent on Ret proto-oncogene activity.";
RL   J. Clin. Endocrinol. Metab. 95:439-444(2010).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
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RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//