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Cellosaurus TGW (CVCL_1771)

[Text version]
Cell line name TGW
Synonyms TOG; TGW-nu; TGW-I-nu; TGW-nu-1
Accession CVCL_1771
Resource Identification Initiative To cite this cell line use: TGW (RRID:CVCL_1771)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 32 hours (Note=Lot 06012007), ~27 hours (Note=Lot 04172014) (JCRB=JCRB0618).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North71.87
East Asian, South26.74
South Asian0.97
European, North0.42
European, South0
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3180 (TGW.P3)CVCL_A443 (TNB1)
Sex of cell Male
Age at sampling 1Y11M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910780; DepMap=ACH-001674; JCRB=JCRB0618

Markers:
AmelogeninX
CSF1PO15
D3S135816
D5S81813
D7S82012
D8S117914
D13S3178,11
D16S5399,13
D18S5114
D21S1130,33.2
FGA23
Penta D9,10
Penta E11,12
TH016,7
TPOX10,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-424.html
Publications

PubMed=2335222; DOI=10.1016/0014-5793(90)81370-4
Yoshiaki Tsuchida, Morimasa Sekiguchi, Yasuhiko Kaneko, Naotoshi Kanda;
Origin of human neuroblastoma cell lines TGW and TNB1.
FEBS Lett. 263:191-191(1990)

PubMed=12210830; DOI=10.1002/jnr.10330
Shinobu Yoshida, Tsutomu Narita, Takashi Taga, Shigeru Ohta, Yoshihiro Takeuchi;
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
J. Neurosci. Res. 69:642-652(2002)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0618
Cell line databases/resources CLO; CLO_0009830
cancercelllines; CVCL_1771
Cell_Model_Passport; SIDM00324
Cosmic-CLP; 910780
DepMap; ACH-001674
LINCS_LDP; LCL-1962
Lonza; 1191
Biological sample resources BioSample; SAMN03471635
CRISP screens repositories BioGRID_ORCS_Cell_line; 1037
Chemistry resources ChEMBL-Cells; CHEMBL3308792
ChEMBL-Targets; CHEMBL1075600
GDSC; 910780
PharmacoDB; TGW_1592_2019
PubChem_Cell_line; CVCL_1771
Encyclopedic resources Wikidata; Q54972266
Experimental variables resources EFO; EFO_0022441
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM314028
GEO; GSM333815
GEO; GSM1670542
Polymorphism and mutation databases Cosmic; 801749
Cosmic; 910780
Cosmic; 920238
Cosmic; 947703
Cosmic; 1037349
Cosmic; 1099146
Cosmic; 1153801
Cosmic; 2131589
Progenetix; CVCL_1771
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39