• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg209Lysfs*6 (c.626_627delGA); ClinVar=VCV000372539; Zygosity=Heterozygous (Cosmic-CLP=910701; DepMap=ACH-000188).
  

PubMed=7214336
James George Rheinwald, Michael A. Beckett;
Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.
Cancer Res. 41:1657-1663(1981)

PubMed=6722007; DOI=10.1038/bjc.1984.94; PMCID=PMC1976725
Ralph R. Weichselbaum, William K. Dahlberg, John Bertram Little, Thomas J. Ervin, Daniel Miller, Samuel Hellman, James George Rheinwald;
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Br. J. Cancer 49:595-601(1984)

PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364
Ralph R. Weichselbaum, William K. Dahlberg, Michael A. Beckett, Theodore Karrison, Daniel Miller, John Clark, Thomas J. Ervin;
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3539321
Beverly A. Teicher, Sylvia A. Holden, Michael J. Kelley, Thomas C. Shea, Carol A. Cucchi, Andre Rosowsky, W. David Henner, Emil Frei 3rd;
Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).
Cancer Res. 47:388-393(1987)

PubMed=3138611; DOI=10.1177/019459988809800603
Thomas P.U. Wustrow, Alexander Raffael, Gunter K. Valet;
Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.
Otolaryngol. Head Neck Surg. 98:552-557(1988)

PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3
Jeffrey L. Schwartz, Jacob Rotmensch, Susan Giovanazzi, Marvin B. Cohen, Ralph R. Weichselbaum;
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988)

PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0
Ralph R. Weichselbaum, Michael A. Beckett, Jeffrey L. Schwartz, Anatoly Dritschilo;
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988)

PubMed=2573646; DOI=10.1080/09553008914551731
Ralph R. Weichselbaum, Jacob Rotmensch, Sijsan Ahmed-Swan, Michael A. Beckett;
Radiobiological characterization of 53 human tumor cell lines.
Int. J. Radiat. Biol. 56:553-560(1989)

PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8
Dennis E. Hallahan, Michael A. Beckett, Donald William Kufe, Ralph R. Weichselbaum;
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990)

PubMed=1394225
Kenneth D. Somers, M. Anne Merrick, Martha E. Lopez, Leonard S. Incognito, Gary L. Schechter, Graham Casey;
Frequent p53 mutations in head and neck cancer.
Cancer Res. 52:5997-6000(1992)

PubMed=1574572; DOI=10.2307/3578273
Edward J. Dunphy, Michael A. Beckett, Lawrence H. Thompson, Ralph R. Weichselbaum;
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8339273
David G. Brachman, Michael A. Beckett, Deborah Graves, Daniel Haraf, Everett E. Vokes, Ralph R. Weichselbaum;
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Cancer Res. 53:3667-3669(1993)

PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513
Julie E. Burns, M.C. Baird, Louise J. Clark, Philip A. Burns, Kirsten Gilian Edington, Charlotte Chapman, Roy Mitchell, Gordon Robertson, David Soutar, Eric Kenneth Parkinson;
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
K. Nakaya, Hidehisa D. Yamagata, Norimasa Arita, Koh-ichi Nakashiro, Masato Nose, Tetsuro Miki, Hiroyuki Hamakawa;
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=20014447; DOI=10.1002/hed.21311; PMCID=PMC2930055
Ivy F.L. Tsui, Cathie Garnis;
Integrative molecular characterization of head and neck cancer cell model genomes.
Head Neck 32:1143-1160(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam ...Show all 22 authors... , Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks, Jennifer Rubin Grandis, David Sidransky ...Show all 15 authors... , Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22006338; DOI=10.1073/pnas.1114669108; PMCID=PMC3203814
Nicholas J. Wang, Zachary Sanborn, Kelly L. Arnett, Laura J. Bayston, Wilson Liao, Charlotte Mary Proby, Irene May Leigh, Eric A. Collisson, Patricia B. Gordon, Lakshmi R. Jakkula, Sally Pennypacker, Yong Zou, Mimansa Sharma ...Show all 33 authors... , Jeffrey P. North, Swapna S. Vemula, Theodora M. Mauro, Isaac M. Neuhaus, Philip E. LeBoit, Joe S. Hur, Kyunghee Park, Nam Huh, Pui-Yan Kwok, Sarah T. Arron, Pierre Pascal Massion, Allen E. Bale, David Haussler, James Edward Cleaver, Joe W. Gray, Paul T. Spellman, Andrew P. South, Jon Christopher Aster, Stephen Charles Blacklow, Raymond J. Cho; Show fewer authors
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray ...Show all 61 authors... , Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028; PMCID=PMC3378915
Martin Degen, Easwar Natarajan, Patricia Barron, Hans R. Widlund, James George Rheinwald;
MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin gamma2 expression in oral dysplasia and squamous cell carcinoma.
Am. J. Pathol. 180:2462-2478(2012)

PubMed=22564525; DOI=10.1158/0008-5472.CAN-12-0423; PMCID=PMC3428932
Stephen J. Goldie, Klaas W. Mulder, David Wei-Min Tan, Scott K. Lyons, Andrew H. Sims, Fiona Mary Watt;
FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.
Cancer Res. 72:3424-3436(2012)

PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410
Keiko Akagi, Jing-Feng Li, Tatevik R. Broutian, Hesed Maria Padilla-Nash, Wei-Hong Xiao, Bo Jiang, James W. Rocco, Theodoros Null Teknos, Bhavna Kumar, Danny Wangsa, Dan He, Thomas Ried, David E. Symer ...Show all 14 authors... , Maura Lianne Gillison; Show fewer authors
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=24825747; DOI=10.1530/ERC-14-0102
Yi-Lin Chang, Yu-Kan Hsu, Tsung-Fan Wu, Chieh-Ming Huang, Li-Yin Liou, Ya-Wen Chiu, Yu-Hsuan Hsiao, Fuh-Jinn Luo, Ta-Chun Yuan;
Regulation of estrogen receptor alpha function in oral squamous cell carcinoma cells by FAK signaling.
Endocr. Relat. Cancer 21:555-565(2014)

PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406
Daniel Martin, Martin C. Abba, Alfredo Alberto Molinolo, Lynn Vitale-Cross, Zhi-Yong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind;
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau, Jens Reeder, Yi Cao ...Show all 30 authors... , Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436
Aditya Stanam, Laurie Love-Homan, Tisha S. Joseph, Madelyn Espinosa-Cotton, Andrean L. Simons;
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27664486; DOI=10.1016/j.arcmed.2016.07.007
Avishai Gavish, Ella Krayzler, Rafael Nagler;
Tumor growth and cell proliferation rate in human oral cancer.
Arch. Med. Res. 47:271-274(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers, Michael A. Davies, Wan-Leng Deng ...Show all 25 authors... , Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel, Jing Wang, Mitchell J. Frederick ...Show all 16 authors... , Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=29423072; DOI=10.18632/oncotarget.23248; PMCID=PMC5790489
Teresa Bernadette Steinbichler, Alshaimaa Abdelmoez, Veronika Maria Metzler, Daniel Dejaco, Herbert Riechelmann, Jozef Dudas, Ira-Ida Skvortsova;
Epithelial-mesenchymal crosstalk induces radioresistance in HNSCC cells.
Oncotarget 9:3641-3652(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim ...Show all 68 authors... , Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji, Dale A. Porter, Tomas Rejtar ...Show all 20 authors... , Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)