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Cellosaurus SBC-1 (CVCL_1676)

[Text version]
Cell line name SBC-1
Synonyms SBC1; Lc817; LC817
Accession CVCL_1676
Secondary accession CVCL_D230
Resource Identification Initiative To cite this cell line use: SBC-1 (RRID:CVCL_1676)
Comments Problematic cell line: Possibly misidentified/contaminated. Shown to be identical to SBC-2 (JCRB web site and STR profile).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 20.4 hours (PubMed=8286010); ~40 hours (Note=Lot 11012007) (JCRB=JCRB0816).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:2348; CREBBP; Simple; p.Gly48Ter (c.142G>T); Zygosity=Heterozygous (Cosmic-CLP=713885; DepMap=ACH-002196).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu112Ter (c.334G>T); ClinVar=VCV001730509; Zygosity=Homozygous (Cosmic-CLP=713885; DepMap=ACH-002196).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys120Ter (c.358A>T); ClinVar=VCV000012363; Zygosity=Homozygous (Cosmic-CLP=713885; DepMap=ACH-002196).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.47
East Asian, North73.66
East Asian, South25.87
South Asian0
European, North0
European, South0
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_W531 ! SBC-2 [Human SCLC]
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=713885; JCRB=JCRB0816

Markers:
AmelogeninX
CSF1PO10,12
D5S8189,11
D7S82011,12
D13S31712
D16S5399
TH018,9
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

DOI=10.2482/haigan.22.53
Shunkichi Hiraki, Masahiro Miyai, Takumi Seto, Tetsuo Tamura, Yoichi Watanabe, Shiro Ozawa, Hiromasa Ikeda, Yasunori Nakata, Taisuke Ohnoshi, Ikuro Kimura;
Establishment of human continuous cell lines from squamous cell, adeno- and small cell carcinoma of the lung and the results of heterotransplantation.
Nihon Haigan Gakkai 22:53-58(1982)

CLPUB00132
Nobuyasu Kishimoto, Taisuke Ohnoshi, Shunkichi Hiraki, Kenishi Miyake, Shiro Ozawa, Tetsuo Tamura, Takeyuki Numata, Shin Kawahara, Ryo Tamura, Hiroaki Miyamoto, Kenji Nishii, Ikuro Kimura;
Establishment and characterization of five cell lines from human small cell carcinoma of the lung.
Nihon Haigan Gakkai 24:644-644(1984)

PubMed=2540905
Takashi Takahashi, Yuichi Obata, Yoshitaka Sekido, Toyoaki Hida, Ryuzo Ueda, Hiroyoshi Watanabe, Yutaka Ariyoshi, Takahiko Sugiura, Toshitada Takahashi;
Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics.
Cancer Res. 49:2683-2688(1989)

DOI=10.4044/joma1947.104.9-10_905
Nobuyasu Kishimoto;
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques. Part 2. Biological characteristics of five newly established small cell lung cancer cell lines.
Okayama Igakkai Zasshi 104:905-913(1992)

PubMed=8286010
Katsuyuki Kiura, Shinobu Watarai, Takuo Shibayama, Taisuke Ohnoshi, Ikuro Kimura, Tatsuji Yasuda;
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9413215
Hiromishi Yamane, Katsuyuki Kiura, Masahiro Tabata, Akihiro Bessho, Tadashi Tsuchida, Kinya Motoda, Akio Hiraki, Hiroshi Ueoka, Mine Harada;
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Toshiki Funakoshi, Isao Tachibana, Yoshihiko Hoshida, Hiromi Kimura, Yoshito Takeda, Takashi Kijima, Kazumi Nishino, Hiroyuki Goto, Tsutomu Yoneda, Toru Kumagai, Tadashi Osaki ...Show all 14 authors... , Seiji Hayashi, Katsuyuki Aozasa, Ichiro Kawase; Show fewer authors
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=17270020; DOI=10.1111/j.1349-7006.2006.00383.x; PMCID=PMC11159027
Saori Koshida, Daisuke Kobayashi, Ryosuke Moriai, Naoki Tsuji, Naoki Watanabe;
Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis.
Cancer Sci. 98:315-320(2007)

PubMed=18937546; DOI=10.1089/jir.2008.0035
Terufumi Kubo, Shingo Ichimiya, Akiko Tonooka, Tsutomu Nagashima, Tomoki Kikuchi, Noriyuki Sato;
p63 induces CD4+ T-cell chemoattractant TARC/CCL17 in human epithelial cells.
J. Interferon Cytokine Res. 28:725-732(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22399608
Tadashi Tsuchida, Hiromishi Yamane, Nobuaki Ochi, Takayuki Tabayashi, Akio Hiraki, Naoyuki Nogami, Nagio Takigawa, Katsuyuki Kiura, Mitsune Tanimoto;
Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer.
Anticancer Res. 32:887-892(2012)

PubMed=25120651; DOI=10.3892/ol.2014.2234; PMCID=PMC4114630
Makoto Suzuki, Koei Ikeda, Kenji Shiraishi, Ayami Eguchi, Takeshi Mori, Kentaro Yoshimoto, Hidekatsu Shibata, Takaaki Ito, Yoshifumi Baba, Hideo Baba;
Aberrant methylation and silencing of IRF8 expression in non-small cell lung cancer.
Oncol. Lett. 8:1025-1030(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0816
JCRB; NIHS0676 - Discontinued
Cell line databases/resources CLO; CLO_0037041
cancercelllines; CVCL_1676
Cell_Model_Passport; SIDM00365
Cosmic-CLP; 713885
DepMap; ACH-002196
LINCS_LDP; LCL-1865
Anatomy/cell type resources BTO; BTO_0005442
Biological sample resources BioSample; SAMN03472514
Chemistry resources ChEMBL-Cells; CHEMBL3308214
ChEMBL-Targets; CHEMBL2366327
GDSC; 713885
PharmacoDB; SBC1_1347_2019
PubChem_Cell_line; CVCL_1676
Encyclopedic resources Wikidata; Q54902178
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM986190
GEO; GSM1670404
Polymorphism and mutation databases Cosmic; 713885
Cosmic; 1995623
IARC_TP53; 27235
Progenetix; CVCL_1676
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43