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Cellosaurus ONS-76 (CVCL_1624)

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Cell line name ONS-76
Synonyms ONS76; Osaka Neurological Surgery-76
Accession CVCL_1624
Resource Identification Initiative To cite this cell line use: ONS-76 (RRID:CVCL_1624)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 18.6 hours (CelloPub=CLPUB00094; PubMed=2504489; PubMed=2818910); 22 +- 0.3 hours (PubMed=31346954); ~24 hours (Note=Lot 08192008), ~32 hours (Note=Lot 12042014) (JCRB=IFO50355).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (Cosmic-CLP=909248; DepMap=ACH-000776).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (Cosmic-CLP=909248; DepMap=ACH-000776).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,26:03
HLA-BB*54:01,54:01
HLA-CC*01:02,03:03
Class II
HLA-DRDRB1*07:01,09:07
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.13
Native American0
East Asian, North83.83
East Asian, South8.46
South Asian0
European, North0
European, South4.58
Disease Medulloblastoma, SHH-activated, TP53-wildtype (NCIt: C129443)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S734 (ONS-B11)CVCL_S735 (ONS-F11)CVCL_S736 (ONS-F8)
Sex of cell Female
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909248; JCRB=IFO50355; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,19
D3S135815
D5S8189,10
D7S82011,12
D8S117910
D13S3178,13
D16S5399,10
D18S5114,21
D19S43314,15.2
D21S1129,30.3
FGA24
Penta D12,13
Penta E15,16
TH019
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=2504489
Kazuyoshi Tamura, Keiji Shimizu, Masanobu Yamada, Yutaka Okamoto, Yutaka Matsui, Kae Chang Park, Eiichiro Mabuchi, Shusuke Moriuchi, Heitaro Mogami;
Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.
Cancer Res. 49:5380-5384(1989)

PubMed=2818910
Masanobu Yamada, Keiji Shimizu, Kazuyoshi Tamura, Yutaka Okamoto, Yutaka Matsui, Shusuke Moriuchi, Kae Chang Park, Eiichiro Mabuchi, Kazumi Yamamoto, Toru Hayakawa, Heitaro Mogami;
Establishment and biological characterization of human medulloblastoma cell lines.
No To Shinkei 41:695-702(1989)

CLPUB00094
Keiji Shimizu, Masanobu Yamada, Shusuke Moriuchi, Kazuyoshi Tamura, Yutaka Okamoto, Kae Chang Park, Eiichiro Mabuchi, Yasuyoshi Miyao, Toru Hayakawa;
Human medulloblastoma cell lines: ONS-76 and ONS-81.
Hum. Cell 3:265-266(1990)

DOI=10.1007/978-4-431-68150-2_63
Keiji Shimizu, Masanobu Yamada, Shusuke Moriuchi, Kazuyoshi Tamura, Eiichiro Mabuchi, Yutaka Okamoto, Yasuyoshi Miyao, Kae Chang Park, Toru Hayakawa;
Biological characterization of human medulloblastoma (ONS-76 and ONS-81) cell lines.
(In book chapter) Biological aspects of brain tumors. Proceedings of the 8th Nikko brain tumor conference, Karatsu (Saga) 1990; Tabuchi, Kazuo (eds.); pp.442-446; Springer; Tokyo; Japan (1991)

PubMed=1992917
Eiichiro Mabuchi, Keiji Shimizu, Masanobu Yamada, Shusuke Moriuchi, Kae Chang Park, Kazuyoshi Tamura, Toru Hayakawa, Heitaro Mogami;
In vitro chemosensitivity test with several antitumor agents against eight malignant brain tumor cell-lines.
Gan To Kagaku Ryoho 18:233-238(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Monica Nister, Bengt Westermark;
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22951319; DOI=10.1093/jrr/rrs078; PMCID=PMC3534279
Lue Sun, Takashi Moritake, Yun-Wen Zheng, Kenshi Suzuki, Ariungerel Gerelchuluun, Zheng-Shan Hong, Junko Zenkoh, Hideki Taniguchi, Koji Tsuboi;
In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76.
J. Radiat. Res. 54:61-69(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31346954; DOI=10.1007/s10616-019-00332-3; PMCID=PMC6787134
Ricardo Bonfim Silva, Karina Bezerra Salomao, Thais Valeria Costa de Andrade Pimentel, Camila Cristina Branquinho de Oliveira Menezes, Patricia Vianna Bonini Palma, Aparecida Maria Fontes;
Biological characterization of the UW402, UW473, ONS-76 and DAOY pediatric medulloblastoma cell lines.
Cytotechnology 71:893-903(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) BCRJ; 0294
JCRB; IFO50355
Cell line databases/resources CLO; CLO_0009900
cancercelllines; CVCL_1624
Cell_Model_Passport; SIDM00567
Cosmic-CLP; 909248
DepMap; ACH-000776
LINCS_LDP; LCL-1578
Biological sample resources BioSample; SAMN03470886
BioSample; SAMN10988186
CRISP screens repositories BioGRID_ORCS_Cell_line; 513
Chemistry resources ChEMBL-Cells; CHEMBL3308540
ChEMBL-Targets; CHEMBL2366068
GDSC; 909248
PharmacoDB; ONS76_1201_2019
PubChem_Cell_line; CVCL_1624
Encyclopedic resources Wikidata; Q54936426
Experimental variables resources EFO; EFO_0022571
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10759-110E3
GEO; GSM887477
GEO; GSM888558
GEO; GSM919364
GEO; GSM1670306
Polymorphism and mutation databases Cosmic; 909248
Cosmic; 1995603
IARC_TP53; 21602
LiGeA; CCLE_428
Progenetix; CVCL_1624
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number45