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Cellosaurus NB69 (CVCL_1448)

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Cell line name NB69
Synonyms NB-69; NB_69; NB 69; NB69-RIKEN
Accession CVCL_1448
Resource Identification Initiative To cite this cell line use: NB69 (RRID:CVCL_1448)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.26
East Asian, North0.67
East Asian, South0
South Asian0.54
European, North64.54
European, South34
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y4M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=908440; ECACC=99072802; PubMed=25877200; RCB=RCB0480

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817,23
D3S135816,17
D5S81811,12
D7S82010
D8S117913.2,14,15
D13S3178
D16S5399,11
D18S5115,16
D19S43314,15
D21S1130.2,31.2,32
FGA21,25
Penta D7,12
Penta E10,13
TH018
TPOX8,11 (Cosmic-CLP=908440; PubMed=25877200; RCB=RCB0480)
11 (ECACC=99072802)
vWA17,18

Run an STR similarity search on this cell line
Publications

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 99072802
RCB; RCB0480
Cell line databases/resources CLO; CLO_0050263
cancercelllines; CVCL_1448
Cell_Model_Passport; SIDM00244
Cosmic-CLP; 908440
DepMap; ACH-002083
LINCS_LDP; LCL-1999
Anatomy/cell type resources BTO; BTO_0005426
Biological sample resources BioSample; SAMN03470996
CRISP screens repositories BioGRID_ORCS_Cell_line; 951
Chemistry resources ChEMBL-Cells; CHEMBL3308799
ChEMBL-Targets; CHEMBL1075510
GDSC; 908440
PharmacoDB; NB69_993_2019
PubChem_Cell_line; CVCL_1448
Encyclopedic resources Wikidata; Q54907543
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM313807
GEO; GSM563353
GEO; GSM827391
GEO; GSM1670154
GEO; GSM2371245
GEO; GSM2394385
GEO; GSM3145588
GEO; GSM3145725
GEO; GSM4104585
GEO; GSM4104586
GEO; GSM4104632
GEO; GSM4104633
GEO; GSM4104634
GEO; GSM4105323
GEO; GSM4105324
GEO; GSM4105325
GEO; GSM4105326
GEO; GSM4105327
Polymorphism and mutation databases Cosmic; 688081
Cosmic; 801739
Cosmic; 908440
Cosmic; 920248
Cosmic; 930069
Cosmic; 947709
Cosmic; 1019930
Cosmic; 1037342
Cosmic; 1099139
Cosmic; 1109123
Cosmic; 1153787
Cosmic; 1890119
Cosmic; 2058110
Cosmic; 2131577
IARC_TP53; 21531
IARC_TP53; 27184
Progenetix; CVCL_1448
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number45