ID   NB69
AC   CVCL_1448
SY   NB-69; NB_69; NB 69; NB69-RIKEN
DR   BTO; BTO_0005426
DR   CLO; CLO_0050263
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 951
DR   BioSample; SAMN03470996
DR   cancercelllines; CVCL_1448
DR   Cell_Model_Passport; SIDM00244
DR   ChEMBL-Cells; CHEMBL3308799
DR   ChEMBL-Targets; CHEMBL1075510
DR   Cosmic; 688081
DR   Cosmic; 801739
DR   Cosmic; 908440
DR   Cosmic; 920248
DR   Cosmic; 930069
DR   Cosmic; 947709
DR   Cosmic; 1019930
DR   Cosmic; 1037342
DR   Cosmic; 1099139
DR   Cosmic; 1109123
DR   Cosmic; 1153787
DR   Cosmic; 1890119
DR   Cosmic; 2058110
DR   Cosmic; 2131577
DR   Cosmic-CLP; 908440
DR   DepMap; ACH-002083
DR   ECACC; 99072802
DR   EGA; EGAS00001000978
DR   GDSC; 908440
DR   GEO; GSM313807
DR   GEO; GSM563353
DR   GEO; GSM827391
DR   GEO; GSM1670154
DR   GEO; GSM2371245
DR   GEO; GSM2394385
DR   GEO; GSM3145588
DR   GEO; GSM3145725
DR   GEO; GSM4104585
DR   GEO; GSM4104586
DR   GEO; GSM4104632
DR   GEO; GSM4104633
DR   GEO; GSM4104634
DR   GEO; GSM4105323
DR   GEO; GSM4105324
DR   GEO; GSM4105325
DR   GEO; GSM4105326
DR   GEO; GSM4105327
DR   IARC_TP53; 21531
DR   IARC_TP53; 27184
DR   LINCS_LDP; LCL-1999
DR   PharmacoDB; NB69_993_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1448
DR   PubChem_Cell_line; CVCL_1448
DR   RCB; RCB0480
DR   Wikidata; Q54907543
RX   DOI=10.1007/0-306-46872-7_2;
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   PubMed=16822308;
RX   PubMed=18923524;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=23202128;
RX   PubMed=25877200;
RX   PubMed=27397505;
RX   PubMed=28350380;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Genomics; ChIP-seq; H3K4me1.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; Chromatin accessibility; ATAC-seq.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.26%; East Asian, North=0.67%; East Asian, South=0%; South Asian=0.54%; European, North=64.54%; European, South=34% (PubMed=30894373).
ST   Source(s): Cosmic-CLP=908440; ECACC=99072802; PubMed=25877200; RCB=RCB0480
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8
ST   D16S539: 9,11
ST   D18S51: 15,16
ST   D19S433: 14,15
ST   D21S11: 30.2,31.2,32
ST   D2S1338: 17,23
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 13.2,14,15
ST   FGA: 21,25
ST   Penta D: 7,12
ST   Penta E: 10,13
ST   TH01: 8
ST   TPOX: 8,11 (Cosmic-CLP=908440; PubMed=25877200; RCB=RCB0480)
ST   TPOX: 11 (ECACC=99072802)
ST   vWA: 17,18
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1Y4M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 45
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315;
RA   Harenza, Jo Lynne
RA   Diamond, Maura A.
RA   Adams, Rebecca N.
RA   Song, Michael M.
RA   Davidson, Heather L.
RA   Hart, Lori S.
RA   Dent, Maiah H.
RA   Fortina, Paolo
RA   Reynolds, Charles Patrick
RA   Maris, John Matthew
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033.1-170033.8(2017).
//
RX   PubMed=18923524; DOI=10.1038/nature07399;
RA   Chen, Yu-Yan
RA   Takita, Junko
RA   Choi, Young Lim
RA   Kato, Motohiro
RA   Ohira, Miki
RA   Sanada, Masashi
RA   Wang, Li-Li
RA   Soda, Manabu
RA   Kikuchi, Akira
RA   Igarashi, Takashi
RA   Nakagawara, Akira
RA   Hayashi, Yasuhide
RA   Mano, Hiroyuki
RA   Ogawa, Seishi
RT   "Oncogenic mutations of ALK kinase in neuroblastoma.";
RL   Nature 455:971-974(2008).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel, Mark A.
RA   Thiele, Carol Jeanne
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele, Carol Jeanne
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846;
RA   Dam, Vincent
RA   Morgan, Brian T.
RA   Mazanek, Pavel
RA   Hogarty, Michael D.
RT   "Mutations in PIK3CA are infrequent in neuroblastoma.";
RL   BMC Cancer 6:177.1-177.10(2006).
//
RX   PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959;
RA   Sausen, Mark
RA   Leary, Rebecca J.
RA   Jones, Sian
RA   Wu, Jian
RA   Reynolds, Charles Patrick
RA   Liu, Xue-Yuan
RA   Blackford, Amanda L.
RA   Parmigiani, Giovanni
RA   Diaz, Luis Alberto Jr.
RA   Papadopoulos, Nickolas
RA   Vogelstein, Bert
RA   Kinzler, Kenneth Wayne
RA   Velculescu, Victor E.
RA   Hogarty, Michael D.
RT   "Integrated genomic analyses identify ARID1A and ARID1B alterations in
RT   the childhood cancer neuroblastoma.";
RL   Nat. Genet. 45:12-17(2013).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//