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Cellosaurus NB1 (CVCL_1440)

[Text version]
Cell line name NB1
Synonyms NB-1; NB-I; NB 1
Accession CVCL_1440
Resource Identification Initiative To cite this cell line use: NB1 (RRID:CVCL_1440)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 40-50 hours (PubMed=174024); ~1 day (Note=Lot 12092005), ~32 hours (Note=Lot 09252019) (JCRB=IFO50295); ~60 hours (Note=Lot 120898), ~2 days (Note=Lot 08152016) (JCRB=JCRB0621).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (Cosmic-CLP=949179; DepMap=ACH-000804).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.29
Native American0.21
East Asian, North80.53
East Asian, South13.17
South Asian0
European, North0
European, South3.8
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y3M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=949179; JCRB=IFO50295; JCRB=JCRB0621; PubMed=25877200; RCB=RCB1953; TKG=TKG 0486

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,27
D3S135815,17
D5S8189,11
D7S8208,12 (Cosmic-CLP=949179; JCRB=IFO50295; JCRB=JCRB0621; PubMed=25877200; RCB=RCB1953)
12 (TKG=TKG 0486)
D8S117912,16
D13S31710,13
D16S5399 (Cosmic-CLP=949179; JCRB=IFO50295; JCRB=JCRB0621; PubMed=25877200; TKG=TKG 0486)
9,12 (RCB=RCB1953)
D18S5116
D19S43313.2,15.2
D21S1130,31.2
FGA19,23
Penta D8,9
Penta E17,18
TH017
TPOX11
vWA16,19

Run an STR similarity search on this cell line
Publications

CLPUB00086
Shizuo Miyake, Yoshihiro Shimo, Tadahisa Kitamura, Yoshiaki Nojo, Tsuneo Nakamura, Shinsaku Imashuku, Tatsuo Abe;
Characteristics of continuous and functional cell line NB-I, derived from a human neuroblastoma.
Jiritsu Shinkei 10:115-120(1973)

PubMed=4144593; DOI=10.1210/jcem-36-5-931
Shinsaku Imashuku, Akihiko Inui, Tsuneo Nakamura, Junichi Tanaka, Shizuo Miyake;
Catecholamine metabolism in tissue culture cells of a neuroblastoma.
J. Clin. Endocrinol. Metab. 36:931-936(1973)

PubMed=174024
Shizuo Miyake, Tadahisa Kitamura, Yoshitaka Shimo;
Morphological differentiation in vitro of human continuous and functional neuroblastoma cell line, NB-I under treatment of (But)2cAMP.
No Shinkei Geka 3:407-414(1975)

PubMed=201151; DOI=10.1111/j.1440-1827.1977.tb00186.x
Shinobu Ishikawa;
Differentiation of human neuroblastoma cells in vitro -- morphological changes induced by dibutyrl cyclic AMP.
Acta Pathol. Jpn. 27:697-711(1977)

PubMed=590688; DOI=10.20772/cancersci1959.68.5_711
Naomi Ohnuma, Tsutomu Kasuga, Ichi Nojiri, Takeshi Furuse;
Radiosensitivity of human neuroblastoma cell line (NB-1).
Gann 68:711-712(1977)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11129446; DOI=10.1097/00019606-200012000-00007
Tohru Sugimoto, Hiroshi Mine, Yoshihiro Horii, Katsuhito Takahashi, Ryozo Nagai, Ryuichi Morishita, Mihiro Komada, Yujiro Asada, Tadashi Sawada;
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Diagn. Mol. Pathol. 9:221-228(2000)

PubMed=12210830; DOI=10.1002/jnr.10330
Shinobu Yoshida, Tsutomu Narita, Takashi Taga, Shigeru Ohta, Yoshihiro Takeuchi;
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
J. Neurosci. Res. 69:642-652(2002)

PubMed=12702577
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa;
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50295
JCRB; JCRB0621
RCB; RCB1953
TKG; TKG 0486
Cell line databases/resources CLO; CLO_0051419
cancercelllines; CVCL_1440
Cell_Model_Passport; SIDM00578
CGH-DB; 74-1
CGH-DB; 9097-4
Cosmic-CLP; 949179
DepMap; ACH-000804
LINCS_LDP; LCL-1977
Anatomy/cell type resources BTO; BTO_0005103
Biological sample resources BioSample; SAMN03470966
BioSample; SAMN03472043
BioSample; SAMN10988531
CRISP screens repositories BioGRID_ORCS_Cell_line; 402
Chemistry resources GDSC; 949179
PharmacoDB; NB1_984_2019
Encyclopedic resources Wikidata; Q54907515
Experimental variables resources EFO; EFO_0022502
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10539-107G8
GEO; GSM333816
GEO; GSM333825
GEO; GSM887348
GEO; GSM888425
GEO; GSM1670145
GEO; GSM2371241
GEO; GSM2394388
GEO; GSM4104581
GEO; GSM4104582
Polymorphism and mutation databases Cosmic; 801736
Cosmic; 920243
Cosmic; 947696
Cosmic; 949179
Cosmic; 1037339
Cosmic; 1099136
Cosmic; 1153784
Cosmic; 1526632
Cosmic; 2131573
IARC_TP53; 27699
LiGeA; CCLE_099
Progenetix; CVCL_1440
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42