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Cellosaurus MUTZ-1 (CVCL_1431)

[Text version]
Cell line name MUTZ-1
Synonyms Mutz-1; MUTZ1; Menschliche Und Tierische Zellkulture-1
Accession CVCL_1431
Resource Identification Initiative To cite this cell line use: MUTZ-1 (RRID:CVCL_1431)
Comments Problematic cell line: Contaminated. Shown to be a Namalwa derivative (PubMed=19344951). Originally thought to originate from a 5 year old girl with myelodysplastic disorder.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00376.
Population: African; Kenyan.
Virology: Contains 2 integrated copies of EBV genome on chromosome 1.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0067 (Namalwa)
Sex of cell Female
Age at sampling Children
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-13

Markers:
AmelogeninX
CSF1PO10,11
D5S81812,13
D7S82011
D13S31711,12
D16S5399
TH017,9.3
TPOX6,11
vWA14

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9168445; DOI=10.3109/10428199709114174
Steube K.G., Gignac S.M., Hu Z.-B., Teepe D., Harms D., Kabisch H., Gaedicke G., Hansen-Hagge T.E., MacLeod R.A.F., Quentmeier H., Drexler H.G.
In vitro culture studies of childhood myelodysplastic syndrome: establishment of the cell line MUTZ-1.
Leuk. Lymphoma 25:345-363(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=19344951; DOI=10.1016/j.leukres.2009.03.005
Drexler H.G., Dirks W.G., MacLeod R.A.F.
Many are called MDS cell lines: one is chosen.
Leuk. Res. 33:1011-1016(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

Cross-references
Cell line collections (Providers) DSMZ; ACC-13 - Discontinued
Cell line databases/resources CLO; CLO_0007901
CLDB; cl3603
cancercelllines; CVCL_1431
Cell_Model_Passport; SIDM00656
Biological sample resources BioSample; SAMN03151853
Encyclopedic resources Wikidata; Q54907097
Gene expression databases ArrayExpress; E-MTAB-783
Polymorphism and mutation databases Cosmic; 908155
Cosmic; 1995516
Cosmic; 2491098
IARC_TP53; 21520
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30