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Cellosaurus MUTZ-1 (CVCL_1431)

[Text version]

Cell line name MUTZ-1
Synonyms Mutz-1; MUTZ1; Menschliche Und Tierische Zellkulture-1
Accession CVCL_1431
Resource Identification Initiative To cite this cell line use: MUTZ-1 (RRID:CVCL_1431)
Comments Problematic cell line: Contaminated. Shown to be a Namalwa derivative (PubMed=19344951). Originally thought to originate from a 5 year old girl with myelodysplastic disorder.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00376.
Population: African; Kenyan.
Characteristics: Contains 2 integrated copies of EBV genome on chromosome 1.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0067 (Namalwa)
Sex of cell Female
Age at sampling Children
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO10,11
D5S81812,13
D7S82011
D13S31711,12
D16S5399
TH017,9.3
TPOX6,11
vWA14

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx
Publications

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9168445; DOI=10.3109/10428199709114174
Steube K.G., Gignac S.M., Hu Z.-B., Teepe D., Harms D., Kabisch H., Gaedicke G., Hansen-Hagge T.E., MacLeod R.A.F., Quentmeier H., Drexler H.G.
In vitro culture studies of childhood myelodysplastic syndrome: establishment of the cell line MUTZ-1.
Leuk. Lymphoma 25:345-363(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=19344951; DOI=10.1016/j.leukres.2009.03.005
Drexler H.G., Dirks W.G., MacLeod R.A.F.
Many are called MDS cell lines: one is chosen.
Leuk. Res. 33:1011-1016(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

Cross-references
Cell line collections DSMZ; ACC-13 - Discontinued
Cell line databases/resources CLO; CLO_0007901
CLDB; cl3603
Cell_Model_Passport; SIDM00656
Biological sample resources BioSample; SAMN03151853
Encyclopedic resources Wikidata; Q54907097
Gene expression databases ArrayExpress; E-MTAB-783
Polymorphism and mutation databases Cosmic; 908155
Cosmic; 1995516
Cosmic; 2491098
IARC_TP53; 21520
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number26