ID   MUTZ-1
AC   CVCL_1431
SY   Mutz-1; MUTZ1; Menschliche Und Tierische Zellkulture-1
DR   CLO; CLO_0007901
DR   CLDB; cl3603
DR   ArrayExpress; E-MTAB-783
DR   BioSample; SAMN03151853
DR   cancercelllines; CVCL_1431
DR   Cell_Model_Passport; SIDM00656
DR   Cosmic; 908155
DR   Cosmic; 1995516
DR   Cosmic; 2491098
DR   DSMZ; ACC-13
DR   IARC_TP53; 21520
DR   Wikidata; Q54907097
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9067587;
RX   PubMed=9168445;
RX   PubMed=19344951;
RX   PubMed=20164919;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a Namalwa derivative (PubMed=19344951). Originally thought to originate from a 5 year old girl with myelodysplastic disorder.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00376.
CC   Population: African; Kenyan.
CC   Virology: Contains 2 integrated copies of EBV genome on chromosome 1.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: DSMZ; ACC-13; true.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): DSMZ=ACC-13
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 9
ST   D5S818: 12,13
ST   D7S820: 11
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 14
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0067 ! Namalwa
SX   Female
AG   Children
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=9067587; DOI=10.1038/sj.leu.2400571;
RA   Uphoff, Cord C.
RA   MacLeod, Roderick A.F.
RA   Denkmann, Sabine A.
RA   Golub, Todd Robert
RA   Borkhardt, Arndt
RA   Janssen, Johannes W.G.
RA   Drexler, Hans Gunther
RT   "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in
RT   human early B-lineage leukemia cell lines.";
RL   Leukemia 11:441-447(1997).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9168445; DOI=10.3109/10428199709114174;
RA   Steube, Klaus G.
RA   Gignac, Suzanne M.
RA   Hu, Zhen-Bo
RA   Teepe, Dorthe
RA   Harms, Dorthe
RA   Kabisch, Hartmut
RA   Gaedicke, Gerhard
RA   Hansen-Hagge, Thomas E.
RA   MacLeod, Roderick A.F.
RA   Quentmeier, Hilmar
RA   Drexler, Hans Gunther
RT   "In vitro culture studies of childhood myelodysplastic syndrome:
RT   establishment of the cell line MUTZ-1.";
RL   Leuk. Lymphoma 25:345-363(1997).
//
RX   PubMed=19344951; DOI=10.1016/j.leukres.2009.03.005;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   MacLeod, Roderick A.F.
RT   "Many are called MDS cell lines: one is chosen.";
RL   Leuk. Res. 33:1011-1016(2009).
//