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Cellosaurus SK-N-MC-IXC (CVCL_1398)

[Text version]
Cell line name SK-N-MC-IXC
Synonyms MC-IXC; MCIXC
Accession CVCL_1398
Resource Identification Initiative To cite this cell line use: SK-N-MC-IXC (RRID:CVCL_1398)
Comments Problematic cell line: Misclassified. Parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2010-067.
Population: Caucasian.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0
East Asian, South0
South Asian0
European, North74.37
European, South25.63
Disease Askin tumor (NCIt: C7542)
Peripheral primitive neuroectodermal tumor (ORDO: Orphanet_370348)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0530 (SK-N-MC)
Children:
CVCL_B0FD (SK-N-MC-IXC/VCR)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2270; Cosmic-CLP=908118; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133817,21
D3S135815
D5S81811
D7S8208
D8S117910
D13S31711
D16S53912
D18S5113,14,15
D19S43313,15.2
D21S1130,31.2
FGA21,25
Penta D9,13
Penta E16,18
TH019.3
TPOX9,11
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-n-mc-ixc-human-neuroblastoma-cell-line
Publications

PubMed=4748425
June Lee Biedler, Lawrence Helson, Barbara A. Spengler;
Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.
Cancer Res. 33:2643-2652(1973)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2270
Cell line databases/resources CLO; CLO_0007615
cancercelllines; CVCL_1398
Cell_Model_Passport; SIDM01246
Cosmic-CLP; 908118
DepMap; ACH-002160
IGRhCellID; MCIXC
LINCS_LDP; LCL-1967
TOKU-E; 4055
Anatomy/cell type resources BTO; BTO_0005372
Biological sample resources BioSample; SAMN03472918
CRISP screens repositories BioGRID_ORCS_Cell_line; 939
Chemistry resources ChEMBL-Cells; CHEMBL3308758
ChEMBL-Targets; CHEMBL1075495
GDSC; 908118
PharmacoDB; MCIXC_886_2019
PubChem_Cell_line; CVCL_1398
Encyclopedic resources Wikidata; Q54954480
Experimental variables resources EFO; EFO_0002230
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
GEO; GSM1670077
Polymorphism and mutation databases Cosmic; 688068
Cosmic; 908118
Progenetix; CVCL_1398
Proteomic databases PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41